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. 2024 Nov 14;187(23):6518-6520.
doi: 10.1016/j.cell.2024.10.033.

Bound by the love for cholesterol: A transporter meets a GPCR

Divyanshu Tiwari  1 , Nabarun Roy  1 , Arun K Shukla  2
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Bound by the love for cholesterol: A transporter meets a GPCR

Divyanshu Tiwari et al. Cell. .

Abstract

In a recently published article in Nature, Bayly-Jones et al. report the cryo-EM structures of a lysosomal cholesterol sensor, LYCHOS, also known as GPR155, which reveals a unique fusion of a plant auxin-transporter-like domain with a seven-transmembrane GPCR-like domain and elucidates mechanistic insights into cellular regulation of mTORC1 activity.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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