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Review
. 2025 Jan;20(1):89-100.
doi: 10.1016/j.cpet.2024.09.015.

Clinical Applications of PET Imaging in Alzheimer's Disease

Shiv Patil  1 , Cyrus Ayubcha  2 , Eric Teichner  1 , Robert Subtirelu  3 , Julia H Cho  4 , Mohanad Ghonim  5 , Mohamed Ghonim  5 , Thomas J Werner  3 , Poul Flemming Høilund-Carlsen  6 , Abass Alavi  3 , Andrew B Newberg  7
Affiliations
Review

Clinical Applications of PET Imaging in Alzheimer's Disease

Shiv Patil et al. PET Clin. 2025 Jan.

Abstract

Alzheimer's disease (AD) involves a complex pathophysiology of neurodegeneration that leads to severe cognitive deficiencies. Understanding the molecular alterations that underlie this disease is fundamental to clinical management and therapeutic innovation. Functional imaging with positron emission tomography (PET) enables a visualization of these impaired pathways, such as cerebral hypometabolism, amyloid and tau accumulation, and neurotransmitter dysfunction. This review discusses the clinical applications of PET in AD and mild cognitive impairment, focusing on relevant original research studies for disease diagnosis, progression, and treatment response.

Keywords: Alzheimer’s disease; Amyloid; Mild cognitive impairment; Positron emission tomography.

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Disclosure The authors have no disclosures to declare.

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