Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1986 Mar 15;35(6):1005-9.
doi: 10.1016/0006-2952(86)90091-2.

Evidence for distinct consecutive steps in the neutral to base transition of human serum albumin

B J t' Hart, J Wilting, J J de Gier

Evidence for distinct consecutive steps in the neutral to base transition of human serum albumin

B J t' Hart et al. Biochem Pharmacol. .

Abstract

The neutral to base transition in human serum albumin has been studied by means of circular dichroism and equilibrium dialysis using nitrazepam as the non-covalently bound circular dichroic probe. Spectroscopically two transitions were observed over the pH range 5.5-8.5, whereas dialysis data point to only one transition occurring in the latter part of the pH region studied. Both pH dependences could only be correlated if it is assumed that the neutral to base transition consists of at least two distinct consecutive steps.

PubMed Disclaimer

LinkOut - more resources