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. 2024 Nov 19;13(22):e033862.
doi: 10.1161/JAHA.123.033862. Epub 2024 Nov 15.

Cardiac Histopathology in Duchenne Muscular Dystrophy Demonstrates Diffuse Fibrofatty Replacement of the Myocardium

Andrea Breaux  1   2 , Sean M Lang  3 , Samuel Wittekind  3 , Thomas D Ryan  3 , Michael Taylor  3 , Eleanor Greiner  3 , Cuixia Tian  4 , Jennifer Kasten  1   2 , Hemant Sawnani  5 , Chet R Villa  3
Affiliations

Cardiac Histopathology in Duchenne Muscular Dystrophy Demonstrates Diffuse Fibrofatty Replacement of the Myocardium

Andrea Breaux et al. J Am Heart Assoc. .
No abstract available

Keywords: Duchenne muscular dystrophy; cardiac fibrosis; histology.

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Figures

Figure 1
Figure 1. Patient characteristics and representative histology samples.
A, Patient characteristics. B, Hematoxylin and eosin stain (1.3×) depicting mixed fibrous and fatty infiltration of the left ventricle from patient 3. C, Hematoxylin and eosin stain of selected right ventricle tissue samples. Fibrofatty infiltration of the right ventricle from cases 5 (0.6×) and 11 (1×) showing fatty infiltration extending from the subepicardial surface and extending toward the endocardial surface. D, Hematoxylin and eosin stain (1×) depicting mixed fibrous (#) and fatty infiltration (*) of the left ventricle from patient 11 corresponding to areas of subepicardial late gadolinium enhancement on cardiac magnetic resonance. E, Summary of histologic findings in each ventricle. D, deflazacort; E, eteplirsen; LVEF, left ventricular ejection fraction; n/a, not available; P, prednisone/prednisolone; and VAD, ventricular assist device.
See this image and copyright information in PMC

References

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