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. 2024 Nov 15;24(1):808.
doi: 10.1186/s12888-024-06269-y.

U-shaped relationship between triglyceride glucose-body mass index and suicide attempts in Chinese patients with untreated first-episode major depressive disorder

Fengnan Jia #  1   2 , He Ma #  1 , Junjun Liu #  3 , Chuanwei Li  1 , Gang Ye  1 , Tao Chen  1 , Ruiping Huo  1 , Xiangdong Du  4   5 , Xiangyang Zhang  6
Affiliations

U-shaped relationship between triglyceride glucose-body mass index and suicide attempts in Chinese patients with untreated first-episode major depressive disorder

Fengnan Jia et al. BMC Psychiatry. .

Abstract

Objective: An alternative metric for evaluating insulin resistance (IR) is the triglyceride glucose-body mass index (TyG-BMI). However, it is yet unclear how TyG-BMI and suicide attempts (SA) are related. The objective of this research was to explore the correlation between the TyG-BMI index and SA in individuals with untreated first-episode (UFE) major depressive disorder (MDD) in Shanxi Province.

Methods: This cross-sectional study was conducted from September 2016 to December 2018 in the psychiatric outpatient clinic of Taiyuan General Hospital and included 1718 patients with UFE MDD, with a mean age of 34.9 ± 12.4 years. The relationship between TyG-BMI and SA was assessed using logistic regression modeling. We investigated threshold effects using a two-piecewise linear regression model.

Results: Taking into consideration the potential influence of confounding variables, a comprehensive multivariate logistic regression analysis was conducted, which demonstrated the absence of a statistically significant association between the TyG-BMI index and the occurrence of SA, as evidenced by P-values that were all greater than 0.05. On the other hand, the visual analysis of the smoothed plots revealed a U-shaped relationship between the TyG-BMI index and the incidence of SA, with a notable inflection occurring at a TyG-BMI value of around 210. It was observed that the effect sizes flanking the inflection point, accompanied by their 95% confidence intervals, were 0.985 (95% CI: 0.972 to 0.999, P = 0.031) and 1.012 (95% CI: 1.003 to 1.047, P = 0.005), respectively.

Conclusions: In UFE MDD patients, a U-shaped link was observed between TyG-BMI and SA, with the minimal SA incidence noted at a TyG-BMI level of 210, signifying that an augmented risk for SA might be connected to both diminished and augmented TyG-BMI levels.

Keywords: Insulin resistance; Major depressive disorder; Suicide attempts; Triglyceride glucose-body mass index.

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Conflict of interest statement

Declarations Ethics approval and consent to participate The research involving human subjects received approval from the Institutional Review Board of the First Hospital, Shanxi Medical University (No. 2016-Y27). All studies were conducted in compliance with local laws and institutional guidelines. Participants provided their written informed consent to take part in the study. Additionally, written informed consent was obtained from the individual(s) for the publication of any potentially identifiable images or data included in this article. Consent for publication Not application. Competing interests The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Flow chart of this study
Fig. 2
Fig. 2
The relationship between TyG-BMI index and the probability of suicide attempts. A nonlinear relationship between TyG-BMI index and the probability of SA was observed after adjusting for age, sex, education, duration of illness, HAMD, HAMA, TSH, A-TPO, TC, HDL-c, LDL-c, SBP, DBP (P for non-linearity < 0.05)
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