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. 2024 Nov;14(11):e70068.
doi: 10.1002/ctm2.70068.

Confirmation of previously identified plasma microRNA ratios for breast cancer detection in a nested case-control study within a screening setting

Emir Sehovic  1 , Ilaria Gregnanin  1 , Maurizia Mello-Grand  1 , Paola Ostano  1 , Viviana Vergini  2 , Andrea Ortale  2 , Angela Amoruso  3 , Elisabetta Favettini  3 , Nereo Segnan  2 , Giovanna Chiorino  1 , Livia Giordano  2 , Elisabetta Petracci  4
Affiliations

Confirmation of previously identified plasma microRNA ratios for breast cancer detection in a nested case-control study within a screening setting

Emir Sehovic et al. Clin Transl Med. 2024 Nov.
No abstract available

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Figures

FIGURE 1
FIGURE 1
Flowchart of the pipeline in which we assessed the discrimination power and calibration of the model on miRNA ratios and nonmolecular variables. *let‐7b‐5p was replaced by let‐7a‐5p in the ratios, due to a high correlation (ρ = .96) of Cts between the two miRNAs within the discovery set and as their mature sequences are almost identical (two nucleotides are different).
FIGURE 2
FIGURE 2
ROC AUC (A) based on the ridge regression on the model with all predictors. Within the ROC curve, the Youden's cut‐off and AUC are reported. (B) Histogram of bootstrapped (2000 sampling iterations) ROC AUC based on the ridge regression. The vertical dashed line represents the ROC AUC obtained in the ridge logistic regression model on the original validation sample. (C) Calibration plot of the ridge regression model on all predictors where the intercept and slope of the calibration curve and the c statistic are shown.
See this image and copyright information in PMC

References

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