ONC201 (Dordaviprone): review of evidence to date in diffuse midline glioma, hope or hype?

Jordan R Hansford^{1

2

3}, Neevika Manoharan^{4

5

6}, Gauthier Bouche⁷, Vijay Ramaswamy^{8

9

10}, Nada Jabado¹¹, Eric Bouffet¹²

Affiliations

¹ Michael Rice Centre for Hematology and Oncology, Women's and Children's Hospital, Adelaide, SA, Australia.
² Paediatric Neuro-Oncology, Cancer Precision Medicine, South Australia Health and Medical Research Institute, Adelaide, SA, Australia.
³ South Australia ImmunoGENomics Cancer Institute, University of Adelaide, Adelaide, SA, Australia.
⁴ Kids Cancer Centre, Sydney Children's Hospital, Randwick, NSW, Australia.
⁵ Children's Cancer Institute, Lowy Cancer Centre, UNSW Sydney, Kensington, NSW, Australia.
⁶ School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Kensington, NSW, Australia.
⁷ The Anticancer Fund, Meise, Belgium.
⁸ Developmental and Stem Cell Biology, Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Canada.
⁹ Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON, Canada.
¹⁰ Departments of Medical Biophysicsand Pediatrics, University of Toronto, Toronto, ON, Canada.
¹¹ Department of Pediatrics, McGill University, RI-MUHC, Glen Site, Montreal, QC, Canada.
¹² The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.

Editorial

Jordan R Hansford et al. Expert Opin Emerg Drugs. 2024 Dec.

. 2024 Dec;29(4):321-325.

doi: 10.1080/14728214.2024.2426649. Epub 2024 Nov 21.

Jordan R Hansford^{1

2

3}, Neevika Manoharan^{4

5

6}, Gauthier Bouche⁷, Vijay Ramaswamy^{8

9

10}, Nada Jabado¹¹, Eric Bouffet¹²

¹ Michael Rice Centre for Hematology and Oncology, Women's and Children's Hospital, Adelaide, SA, Australia.
² Paediatric Neuro-Oncology, Cancer Precision Medicine, South Australia Health and Medical Research Institute, Adelaide, SA, Australia.
³ South Australia ImmunoGENomics Cancer Institute, University of Adelaide, Adelaide, SA, Australia.
⁴ Kids Cancer Centre, Sydney Children's Hospital, Randwick, NSW, Australia.
⁵ Children's Cancer Institute, Lowy Cancer Centre, UNSW Sydney, Kensington, NSW, Australia.
⁶ School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Kensington, NSW, Australia.
⁷ The Anticancer Fund, Meise, Belgium.
⁸ Developmental and Stem Cell Biology, Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Canada.
⁹ Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON, Canada.
¹⁰ Departments of Medical Biophysicsand Pediatrics, University of Toronto, Toronto, ON, Canada.
¹¹ Department of Pediatrics, McGill University, RI-MUHC, Glen Site, Montreal, QC, Canada.
¹² The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.

No abstract available

Keywords: Dordaviprone; ONC201; diffuse midline glioma.

Publication types