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. 2025 Jan 1;10(1):98-100.
doi: 10.1001/jamacardio.2024.4596.

Heart Failure in Zero Gravity-External Constraint and Cardiac Hemodynamics

James P MacNamara  1   2 , Christopher M Hearon Jr  1   2 , Giorgio Manferdelli  1   2 , Aman M Shah  3 , Kevin G Tayon  4 , Ambarish Pandey  2 , Satyam Sarma  1   2 , Benjamin D Levine  1   2
Affiliations

Heart Failure in Zero Gravity-External Constraint and Cardiac Hemodynamics

James P MacNamara et al. JAMA Cardiol. .
No abstract available

Plain language summary

In this case series study, pulmonary artery systolic, diastolic, and mean pressures of 2 participants with obesity and heart failure with preserved ejection fraction were measured at zero gravity during parabolic flight to assess the effect of external constraint on left ventricular filling pressures.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Shah reported consultant fees from Abbott outside the submitted work. Dr Pandey reported receiving research support from the US National Institute of Health; grant funding from Applied Therapeutics and Gilead Sciences; honoraria from serving as an advisor or consultant from Axon Therapies, Bayer, Cytokinetics, Edwards Lifesciences, Emmi Solutions, Lilly, Medtronic, Merck, Novo Nordisk, Rivus, Roche Diagnostics, Sarfex Pharmaceuticals, and Tricog Health outside the submitted work; receiving nonfinancial support from Merck and Pfizer; and serving as a consultant with stock compensation for Palomarin. No other disclosures were reported.

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