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. 1986 Mar;62(3):567-75.
doi: 10.1111/j.1365-2141.1986.tb02969.x.

Lymphocyte doubling time in chronic lymphocytic leukaemia: analysis of its prognostic significance

E Montserrat, J Sanchez-Bisono, N Viñolas, C Rozman

Lymphocyte doubling time in chronic lymphocytic leukaemia: analysis of its prognostic significance

E Montserrat et al. Br J Haematol. 1986 Mar.

Abstract

In 100 untreated patients with chronic lymphocytic leukaemia (CLL) lymphocyte doubling time (LDT) has been investigated in relationship with clinical stages, bone marrow histological patterns, treatment-free period and survival. Although partially correlated with clinical stages and bone marrow patterns, LDT has a clear prognostic significance by itself: whereas a LDT of 12 or less months identifies a population of patients with poor prognosis, a LDT higher than 12 months is indicative of good prognosis as substantiated by a long treatment-free period and survival. This simple parameter can be useful in the clinical management of CLL patients.

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