. 2025 Mar;168(3):608-611.e4.

doi: 10.1053/j.gastro.2024.10.041. Epub 2024 Nov 14.

High Serum Pesticide Levels Are Associated With Increased Odds of Inflammatory Bowel Disease in a Nested Case-Control Study

Manasi Agrawal¹, Ryan C Ungaro², Palak Rajauria², Jared Magee³, Lauren Petrick⁴, Vishal Midya⁵; PREDICTS study collaborators

Collaborators, Affiliations

Collaborators

PREDICTS study collaborators:
Jean-Frederic Colombel², Damaskini Valvi⁵, Amith S Maroli⁵, Brismar Pinto-Pacheco⁵, Joana Torres⁶, Francesca Petralia⁷, Douglas I Walker⁸, Chad Porter⁹, Brooklynn McNeil¹⁰, Joseph Eggers¹¹, Libni A Torres-Olascoaga¹², Jamil M Lane⁵, Syam S Andra⁵, Chris Gennings⁵, Martha M Téllez-Rojo¹², Robert O Wright⁵, Manish Arora⁵, Maria J Rosa⁵, Cecilia S Alcala⁵, Shoshannah Eggers¹¹

Affiliations

¹ The Dr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York; Center for Molecular Prediction of Inflammatory Bowel Disease (PREDICT), Department of Clinical Medicine, Aalborg University, Copenhagen, Denmark. Electronic address: manasi.agrawal@mountsinai.org.
² The Dr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York.
³ Walter Reed National Military Medical Center, Bethesda, Maryland.
⁴ Department of Environmental Medicine and Climate Science, Icahn School of Medicine at Mount Sinai, New York, New York; The Bert Strassburger Metabolic Center, Sheba Medical Center, Tel-Hashomer, Israel.
⁵ Department of Environmental Medicine and Climate Science, Icahn School of Medicine at Mount Sinai, New York, New York.
⁶ Division of Gastroenterology, Hospital Beatriz Ângelo, Loures, Portugal; Division of Gastroenterology, Hospital da Luz, Portugal; Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.
⁷ Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, New York.
⁸ Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia.
⁹ Translational and Clinical Research Department, Naval Medical Research Command, Silver Spring, Maryland.
¹⁰ Irving Institute for Clinical and Translational Research at Columbia University, New York, New York.
¹¹ Department of Epidemiology, University of Iowa College of Public Health, Iowa City, Iowa.
¹² Center for Research on Nutrition and Health, National Institute of Public Health, Cuernavaca, Mexico.

PMID: 39549765
PMCID: PMC11846702 (available on 2026-03-01)
DOI: 10.1053/j.gastro.2024.10.041

High Serum Pesticide Levels Are Associated With Increased Odds of Inflammatory Bowel Disease in a Nested Case-Control Study

Manasi Agrawal et al. Gastroenterology. 2025 Mar.

. 2025 Mar;168(3):608-611.e4.

doi: 10.1053/j.gastro.2024.10.041. Epub 2024 Nov 14.

Authors

Manasi Agrawal¹, Ryan C Ungaro², Palak Rajauria², Jared Magee³, Lauren Petrick⁴, Vishal Midya⁵; PREDICTS study collaborators

Collaborators

PREDICTS study collaborators:
Jean-Frederic Colombel², Damaskini Valvi⁵, Amith S Maroli⁵, Brismar Pinto-Pacheco⁵, Joana Torres⁶, Francesca Petralia⁷, Douglas I Walker⁸, Chad Porter⁹, Brooklynn McNeil¹⁰, Joseph Eggers¹¹, Libni A Torres-Olascoaga¹², Jamil M Lane⁵, Syam S Andra⁵, Chris Gennings⁵, Martha M Téllez-Rojo¹², Robert O Wright⁵, Manish Arora⁵, Maria J Rosa⁵, Cecilia S Alcala⁵, Shoshannah Eggers¹¹

Affiliations

¹ The Dr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York; Center for Molecular Prediction of Inflammatory Bowel Disease (PREDICT), Department of Clinical Medicine, Aalborg University, Copenhagen, Denmark. Electronic address: manasi.agrawal@mountsinai.org.
² The Dr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York.
³ Walter Reed National Military Medical Center, Bethesda, Maryland.
⁴ Department of Environmental Medicine and Climate Science, Icahn School of Medicine at Mount Sinai, New York, New York; The Bert Strassburger Metabolic Center, Sheba Medical Center, Tel-Hashomer, Israel.
⁵ Department of Environmental Medicine and Climate Science, Icahn School of Medicine at Mount Sinai, New York, New York.
⁶ Division of Gastroenterology, Hospital Beatriz Ângelo, Loures, Portugal; Division of Gastroenterology, Hospital da Luz, Portugal; Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.
⁷ Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, New York.
⁸ Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia.
⁹ Translational and Clinical Research Department, Naval Medical Research Command, Silver Spring, Maryland.
¹⁰ Irving Institute for Clinical and Translational Research at Columbia University, New York, New York.
¹¹ Department of Epidemiology, University of Iowa College of Public Health, Iowa City, Iowa.
¹² Center for Research on Nutrition and Health, National Institute of Public Health, Cuernavaca, Mexico.

PMID: 39549765
PMCID: PMC11846702 (available on 2026-03-01)
DOI: 10.1053/j.gastro.2024.10.041

No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflict of interest statement: The corresponding author confirms on behalf of all authors that there have been no involvements that might raise the question of bias in the work reported or in the conclusions, implications, or opinions stated.

MA reports consulting for Douglas Pharmaceutical.

RCU has served as an advisory board member or consultant for AbbVie, Bristol Myers Squibb, Celltrion, Lilly, Janssen, Pfizer, Roivant and Takeda; research support from AbbVie, Boehringer Ingelheim, Bristol Myers Squibb, Lily, and Pfizer.

PR reports no conflict of interest.

JM reports no conflict of interest.

LP reports no conflict of interest.

VM reports no conflict of interest.

JFC reports receiving research grants from AbbVie, Janssen Pharmaceuticals and Takeda; receiving payment for lectures from AbbVie, Amgen, Allergan, Inc. Ferring Pharmaceuticals, Shire, and Takeda; receiving consulting fees from AbbVie, Amgen, Arena Pharmaceuticals, Boehringer Ingelheim, Bristol Myers Squibb, Celgene Corporation, Eli Lilly, Ferring Pharmaceuticals, Galmed Research, Glaxo Smith Kline, Geneva, Iterative Scopes, Janssen Pharmaceuticals, Kaleido Biosciences, Landos, Otsuka, Pfizer, Prometheus, Sanofi, Takeda, TiGenix, and hold stock options in Intestinal Biotech Development.

DV reports no conflict of interest.

ASM reports no conflict of interest.

BPP reports no conflict of interest.

JT has served as an advisory board member or consultant for AbbVie, Bristol Myers Squibb, Janssen, Sandoz, and Pfizer; research support from AbbVie, and Janssen. FP reports no conflict of interest.

DW reports no COI

CP reports no conflict of interest.

BM reports no conflict of interest.

M. Arora is an employee and equity holder of Linus Biotechnology Inc., a start-up company of Mount Sinai Health System. The company develops tools for the detection of autism spectrum disorder and related conditions.

JE reports no conflict of interest.

SE reports no conflict of interest.

References

1. Agrawal M, Hansen AV, Colombel JF, et al. Association between early life exposure to agriculture, biodiversity, and green space and risk of inflammatory bowel disease: a population-based cohort study. EClinicalMedicine 2024;70:102514. doi: 10.1016/j.eclinm.2024.102514 [published Online First: 2024/03/18] - DOI - PMC - PubMed
1. Declercq C, Gower-Rousseau C, Vernier-Massouille G, et al. Mapping of inflammatory bowel disease in northern France: spatial variations and relation to affluence. Inflammatory bowel diseases 2010;16(5):807–12. doi: 10.1002/ibd.21111 [published Online First: 2009/09/24] - DOI - PubMed
1. Chen D, Parks CG, Hofmann JN, et al. Pesticide use and inflammatory bowel disease in licensed pesticide applicators and spouses in the Agricultural Health Study. Environmental research 2024;249:118464. doi: 10.1016/j.envres.2024.118464 [published Online First: 2024/02/15] - DOI - PMC - PubMed
1. Porter CK, Riddle MS, Gutierrez RL, et al. Cohort profile of the PRoteomic Evaluation and Discovery in an IBD Cohort of Tri-service Subjects (PREDICTS) study: Rationale, organization, design, and baseline characteristics. Contemporary clinical trials communications 2019;14:100345. doi: 10.1016/j.conctc.2019.100345 [published Online First: 2019/04/17] - DOI - PMC - PubMed
1. Carrico C, Gennings C, Wheeler DC, et al. Characterization of Weighted Quantile Sum Regression for Highly Correlated Data in a Risk Analysis Setting. J Agric Biol Environ Stat 2015;20(1):100–20. doi: 10.1007/s13253-014-0180-3 [published Online First: 2015/03/01] - DOI - PMC - PubMed

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High Serum Pesticide Levels Are Associated With Increased Odds of Inflammatory Bowel Disease in a Nested Case-Control Study

Collaborators

Affiliations

High Serum Pesticide Levels Are Associated With Increased Odds of Inflammatory Bowel Disease in a Nested Case-Control Study

Authors

Collaborators

Affiliations

Conflict of interest statement

References

Grants and funding

LinkOut - more resources

Full Text Sources