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Review
. 2025 May;50(5):2333-2335.
doi: 10.1007/s00261-024-04700-2. Epub 2024 Nov 18.

The snowflake sign

Davide Castiglione  1 , Francesco Tiralongo  2 , Renato Farina  2 , Emanuele David  2 , Antonio Basile  2
Affiliations
Review

The snowflake sign

Davide Castiglione et al. Abdom Radiol (NY). 2025 May.

Abstract

The "snowflake sign" in liver brucellosis refers to a characteristic appearance on radiological imaging. It is caused by a calcified granuloma within the liver, resulting from a chronic Brucella infection. This calcification often has a distinctive "snowflake" pattern due to its radiating, irregular shape. This sign can be a valuable clue in diagnosing hepatic brucellosis, especially in regions where the disease is endemic.

Keywords: Brucellosis; CT; Calcifications; Liver.

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Conflict of interest statement

Declarations. Competing interests: The authors declare no competing interests.

References

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