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. 2024 Nov 18;409(1):350.
doi: 10.1007/s00423-024-03539-x.

Back to my future: life after surgery for tertiary hyperparathyroidism

Riccardo Morandi  1   2 , Claudio Guarneri  3 , Matteo Nardin  4 , Stefania Maria Filomena Mitola  5 , Nereo Vettoretto  6 , Gianluca Zanni  7 , Elisa Gatta  8   9 , Guido Alberto Massimo Tiberio  7 , Nazario Portolani  7 , Carlo Cappelli  8   9 , Claudio Casella  7   9
Affiliations

Back to my future: life after surgery for tertiary hyperparathyroidism

Riccardo Morandi et al. Langenbecks Arch Surg. .

Abstract

Purposes: Evaluate the changes in quality of life (QoL) in patients affected by tertiary hyperparathyroidism (THPT) after surgical treatment using the Parathyroidectomy Assessment of Symptoms (PAS) and Short Form-36 (SF-36) questionnaires.

Methods: Single centre longitudinal retrospective, single-institution analysis of 34 patients with THPT and submitted to parathyroidectomy between 2015 and 2021. The PAS and SF-36 questionnaires were administered before surgery and 24 months after discharge.

Results: A significative QoL amelioration was registered in physical SF-36 (42.4 ± 11.7 vs 56.7 ± 9.2; P < 0.001), mental SF-36 (47.3 ± 12.1 vs 61.8 ± 7.9; P < 0.001) and PAS score (582 ± 163 vs 293 ± 141; P < 0.001) with a significative improvement of all the 13 symptoms considered. We found that pre-operative intact parathormone (iPTH) levels, preoperative T-score and time of haemodialysis before RTX were predictors of both PAS and SF-36 mental score modifications. A positive correlation was also fund between pre-operative PAS values and their post operative cutback.

Conclusions: Parathyroidectomy for THPT brings to a concrete amelioration of all the disease-related and nonspecific symptoms with significative improvement of QoL. To develop a tailored approach of every patient's needs, from diagnosis to future treatment, we suggest to introduce the symptoms assessment scale as standard stage in periodic evaluations.

Keywords: Parathyroidectomy; Parathyroidectomy assessment of symptoms; Quality of life; Short Form-36; Tertiary hyperparathyroidism.

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Conflict of interest statement

Declarations Ethics approval and consent to participate According to current Italian Law, the approval of the Ethics Committee for a retrospective longitudinal single Institution research study is not required. Informed consent was obtained from all patients. Human and animal rights No humans’/animals’ rights were infringed. Competing interests The authors declare no competing interests.

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