Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Dec;10(6):e70046.
doi: 10.1002/cre2.70046.

A Prediction Model for Lymph Node Metastasis of Oral Squamous Cell Carcinoma Based on Multiple Risk Factors

Hongyu Shen  1   2 , Tonghan Zhang  1   2 , Shuoyu Wang  2
Affiliations

A Prediction Model for Lymph Node Metastasis of Oral Squamous Cell Carcinoma Based on Multiple Risk Factors

Hongyu Shen et al. Clin Exp Dent Res. 2024 Dec.

Abstract

Objectives: Cervical lymph node metastasis (CLNM) frequently occurs in oral cancer patients. This study aims to investigate risk factors associated with CLNM and predict CLNM preoperatively in patients with oral squamous cell carcinoma (OSCC).

Materials and methods: This population-based, hospital retrospective cohort study included 158 patients with oral cancer. We performed regression analysis to determine risk factors and establish a model for predicting CLNM in patients with OSCC. To distinguish and validate the prediction model, we used the area under the receiver operating characteristic (ROC) curve (AUC).

Results: Lymph node size, tumor size, degree of differentiation, and LVI were risk factors for cancer metastasis. The OR values were 1.245, 2.847, 2.527, and 6.945, respectively. The AUC value for the clinical prediction model was 0.8736 (95% CI: 0.8043-0.9429).

Conclusions: The prediction model for OSCC patients predicts CLNM and provides a new method for preoperative assessment of whether cervical lymph nodes are metastatic, as well as a guide for surgical treatment, including whether to carry out neck dissection and which neck dissection procedure to use.

Keywords: cervical lymph node metastasis; oral squamous cell carcinoma; prediction model; risk factors.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
The nomogram prediction model for lymph node metastasis in oral cancer patients.
Figure 2
Figure 2
The ROC curve of the clinical prediction model.
Figure 3
Figure 3
The ROC curve of the clinical prediction model, with tumor size and lymph node size. The red line represents the clinical prediction model, the blue line represents the tumor size model, and the yellow line represents the lymph node size model.
Figure 4
Figure 4
The ROC curve of the validation group.
See this image and copyright information in PMC

References

    1. Abdullah Zubir, A. Z. , Whawell S. A., Wong T. S., and Khurram S. A.. 2020. “The Chemokine Lymphotactin and Its Recombinant Variants in Oral Cancer Cell Regulation.” Oral Diseases 26: 1668–1676. 10.1111/odi.13500. - DOI - PubMed
    1. Aleskandarany, M. A. , Sonbul S. N., Mukherjee A., and Rakha E. A.. 2015. “Molecular Mechanisms Underlying Lymphovascular Invasion in Invasive Breast Cancer.” Pathobiology 82: 113–123. 10.1159/000433583. - DOI - PubMed
    1. Al‐Rajhi, N. , Khafaga Y., El‐Husseiny J., et al. 2000. “Early Stage Carcinoma of Oral Tongue: Prognostic Factors for Local Control and Survival.” Oral Oncology 36: 508–514. 10.1016/s1368-8375(00)00042-7. - DOI - PubMed
    1. de Bree, R. , Takes R. P., Shah J. P., et al. 2019. “Elective Neck Dissection in Oral Squamous Cell Carcinoma: Past, Present and Future.” Oral Oncology 90: 87–93. 10.1016/j.oraloncology.2019.01.016. - DOI - PubMed
    1. d'Alessandro, A. F. , Pinto F. R., Lin C. S., et al. 2015. “Oral Cavity Squamous Cell Carcinoma: Factors Related to Occult Lymph Node Metastasis.” Brazilian Journal of Otorhinolaryngology 81: 248–254. 10.1016/j.bjorl.2015.03.004. - DOI - PMC - PubMed

LinkOut - more resources