Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2025 Jan;103(1):6-8.
doi: 10.1111/imcb.12837. Epub 2024 Nov 17.

Prenatal Skin Cell Atlas reveals macrophages' role beyond immunity

Céline Pattaroni  1
Affiliations
Comment

Prenatal Skin Cell Atlas reveals macrophages' role beyond immunity

Céline Pattaroni. Immunol Cell Biol. 2025 Jan.

Abstract

In this article, we discuss a recently published study by Gopee et al., who have unveiled a surprising role for macrophages in human prenatal skin development, extending far beyond their traditional immune function. By constructing a comprehensive multi-omics single-cell atlas of human prenatal skin, they demonstrate that innate immune cells play a key role in hair follicle formation, scarless wound healing and neurovascular development.

Keywords: Human prenatal skin; Prenatal Skin Cell Atlas; human skin development; immunity; innate immune cells; macrophages.

PubMed Disclaimer

Comment on

  • A prenatal skin atlas reveals immune regulation of human skin morphogenesis.
    Gopee NH, Winheim E, Olabi B, Admane C, Foster AR, Huang N, Botting RA, Torabi F, Sumanaweera D, Le AP, Kim J, Verger L, Stephenson E, Adão D, Ganier C, Gim KY, Serdy SA, Deakin C, Goh I, Steele L, Annusver K, Miah MU, Tun WM, Moghimi P, Kwakwa KA, Li T, Basurto Lozada D, Rumney B, Tudor CL, Roberts K, Chipampe NJ, Sidhpura K, Englebert J, Jardine L, Reynolds G, Rose A, Rowe V, Pritchard S, Mulas I, Fletcher J, Popescu DM, Poyner E, Dubois A, Guy A, Filby A, Lisgo S, Barker RA, Glass IA, Park JE, Vento-Tormo R, Nikolova MT, He P, Lawrence JEG, Moore J, Ballereau S, Hale CB, Shanmugiah V, Horsfall D, Rajan N, McGrath JA, O'Toole EA, Treutlein B, Bayraktar O, Kasper M, Progatzky F, Mazin P, Lee J, Gambardella L, Koehler KR, Teichmann SA, Haniffa M. Gopee NH, et al. Nature. 2024 Nov;635(8039):679-689. doi: 10.1038/s41586-024-08002-x. Epub 2024 Oct 16. Nature. 2024. PMID: 39415002 Free PMC article.

References

REFERENCES

    1. Gopee NH, Winheim E, Olabi B, et al. A prenatal skin atlas reveals immune regulation of human skin morphogenesis. Nature 2024; epub ahead of print 14 October 2024. https://doi.org/10.1038/s41586‐024‐08002‐x
    1. Larson BJ, Longaker MT, Lorenz HP. Scarless fetal wound healing: a basic science review. Plast Reconstr Surg 2010; 126: 1172–1180.
    1. Sinha S, Sparks HD, Labit E, et al. Fibroblast inflammatory priming determines regenerative versus fibrotic skin repair in reindeer. Cell 2022; 185: 4717–4736.e25.
    1. Migliorini A, Ge S, Atkins MH, et al. Embryonic macrophages support endocrine commitment during human pancreatic differentiation. Cell Stem Cell 2024; Epub ahead of print 10 October 2024. https://doi.org/10.1016/j.stem.2024.09.011

LinkOut - more resources