Clinical Trial
Danazol and the premenstrual syndrome
- PMID: 395526
Item in Clipboard
Clinical Trial
Danazol and the premenstrual syndrome
Postgrad Med J.
1979.
Abstract
Danazol as a powerful antigonadotrophin is a logical mode of treatment for patients with premenstrual symptoms. Its preliminary use in a dose 200-800 mg daily is reported. Two groups of patients were treated and of 12 patients with severe symptoms (Group I) six benefited from treatment. The second group (Group II) presenting as fresh cases were given 400 mg daily as the first or second choice of treatment. This group had a high drop out rate and any benefit from treatment was marred by the side effects. Danazol will continue to be used where the symptoms are resistant to other treatment, especially when breast tenderness is predominant. The dose should be the minimum required for relief of symptoms.
Similar articles
-
Premenstrual syndrome: beneficial effects of periodic, low-dose danazol.Obstet Gynecol. 1987 Jul;70(1):33-6. Obstet Gynecol. 1987. PMID: 3299177 Clinical Trial.
-
Danazol treatment of benign breast disease: a survey of U.S.A. multi-centre studies.Postgrad Med J. 1979;55 Suppl 5:52-8. Postgrad Med J. 1979. PMID: 395521 Clinical Trial.
-
Treatment of premenstrual syndrome using danazol: preliminary report of a placebo-controlled, double-blind, dose ranging study.J Int Med Res. 1985;13(2):127-8. doi: 10.1177/030006058501300209. J Int Med Res. 1985. PMID: 3888727 Clinical Trial. No abstract available.
-
Role of danazol in relieving the premenstrual syndrome.J Reprod Med. 1990 Jan;35(1 Suppl):97-102. J Reprod Med. 1990. PMID: 2404119 Review.
-
Efficacy and safety of intranasal buserelin acetate in the treatment of endometriosis: a review of six clinical trials and comparison with danazol.Prog Clin Biol Res. 1990;323:357-82. Prog Clin Biol Res. 1990. PMID: 2106146 Review.
Cited by
-
Update on research and treatment of premenstrual dysphoric disorder.Harv Rev Psychiatry. 2009;17(2):120-37. doi: 10.1080/10673220902891836. Harv Rev Psychiatry. 2009. PMID: 19373620 Free PMC article. Review.
-
The premenstrual syndrome: a review of the present status of therapy.Drugs. 1982 Aug;24(2):140-51. doi: 10.2165/00003495-198224020-00004. Drugs. 1982. PMID: 6749472 Review.