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. 2024 Sep 11;57(5):356-363.
doi: 10.1055/s-0044-1779478. eCollection 2024 Oct.

Focuses and Trends of Research on Platelet-Rich Fibrin: A Bibliometric and Visual Analysis

Ying Zhao  1 , Chen Dong  2 , Liumeizi Fan  1 , Ting Lei  1 , Xin Ge  3 , Zhou Yu  2 , Sheng Hu  1
Affiliations

Focuses and Trends of Research on Platelet-Rich Fibrin: A Bibliometric and Visual Analysis

Ying Zhao et al. Indian J Plast Surg. .

Abstract

Background A rapid expansion of study on platelet-rich fibrin (PRF) has gained more attention in the subject. In this study, bibliometrics were used to assess the outputs and trends of relevant PRF studies. An in-depth analysis of the publication patterns and progress in PRF research worldwide was conducted for the purpose of filling in this research gap. Materials and Methods The analysis included 946 papers sourced from Web of Science that included 842 original articles and 104 reviews. A number of factors including country/region, institution, journal, and author were taken into account. Research on PRF development trends was mapped using the frequency of keywords. Results In terms of the total number of publications, China ranked first with 199 papers, whereas the United States ranked first on the H-index with 37. PRF is an active research area in stomatology and craniomaxillofacial surgery. Keywords provided by the authors were designated to three clusters: red, green, and blue. "Growth factor," "platelet-rich plasma," and "bone regeneration" were the most frequent keywords in each cluster, which reflect the current interests in corresponding fields. Bone regeneration post-dental extractions is one of the main application directions in the field of oral and maxillofacial surgery. "Membrane," "injectable PRF (I-PRF)," "case report," and "advanced PRF (A-PRF)" were relative recent keywords in all clusters, indicating that manufacturing processes and new applications are promising research hotspots in the field. Conclusion In the future, the applications of modified PRF, such as I-PRF, are promising research hotspots. Moreover, strict randomized controlled trials on PRF deserve more attention. The results of this analysis may be helpful for all scholars seeking to expand researches and innovations in the field of PRF.

Keywords: bibliometric analysis; bone regeneration; growth factor; injectable; membrane; platelet-rich fibrin.

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Conflict of interest statement

Conflict of Interest None declared.

Figures

Fig. 1
Fig. 1
Number of publications in the research field of platelet-rich fibrin.
Fig. 2
Fig. 2
The top 10 journals that publish studies on platelet-rich fibrin.
Fig. 3
Fig. 3
Keyword map for platelet-rich fibrin. Various colors indicate three clusters of keywords. Keywords with high frequency are indicated by a large icon.
Fig. 4
Fig. 4
Based on the average appearance date, the distribution of keywords is displayed in blue for early appearances and yellow for recent appearances.
See this image and copyright information in PMC

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