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. 2024 Oct 23:19:Doc46.
doi: 10.3205/dgkh000501. eCollection 2024.

Clovibactin and Staphylococcus aureus: a new weapon against resistant strains

Shuaibu Suleiman Adeiza  1   2
Affiliations

Clovibactin and Staphylococcus aureus: a new weapon against resistant strains

Shuaibu Suleiman Adeiza. GMS Hyg Infect Control. .

Abstract
in English, German

Clovibactin is a new depsipeptide and highly efficacious against Sta p h y l o coccus (S.) aureus, including methicillin-resistant and vancomycin-resistant S. aureus, with no apparent resistance. Clovibactin outclasses current antibiotics such as vancomycin. Here, we discuss its efficacy, emphasize the need for new antibiotics owing to growing global antibiotic resistance, highlight its mode of action and possible benefits over current treatments. We also highlight the challenges involved in large-scale manufacturing and the status of continuing research to advance effective and less toxic derivatives.

Clovibactin ist ein neues Depsipeptid und hoch wirksam gegen Staphylococcus (S.) aureus, einschließlich Methicillin-resistentem und Vancomycin-resistentem S. aureus ohne erkennbare Resistenz. Clovibactin übertrifft die derzeitigen Antibiotika wie Vancomycin. Wir erörtern hier die Wirksamkeit, den dringenden Bedarf an neuen Antibiotika aufgrund der weltweit zunehmenden Antibiotikaresistenz, den Wirkungsmechanismus und mögliche Vorteile gegenüber den derzeitigen Behandlungen. Außerdem werden die Probleme bei der Herstellung in großem Maßstab und der Stand der Forschung zur Entwicklung wirksamer und weniger toxischer Derivate beleuchtet.

Keywords: Eleftheria terrae; Staphylococcus aureus; antimicrobial resistance; clovibactin.

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Conflict of interest statement

The author affirms that he has no competing interests.

Figures

Figure 1
Figure 1. Three-dimensional structure of clovibactin, teixobactin, kalimantacin and vancomycin
Figure 2
Figure 2. Cultivation of bacteria using the iChip device
Figure 3
Figure 3. Mechanism of action. Diagrams show how clovibactin interacts with the peptidoglycan layer of S. aureus and inhibits cell wall synthesis.
Figure 4
Figure 4. Current and future hot spot in clovibactin research
See this image and copyright information in PMC

References

    1. Halawa EM, Fadel M, Al-Rabia MW, Behairy A, Nouh NA, Abdo M, Olga R, Fericean L, Atwa AM, El-Nablaway M, Abdeen A. Antibiotic action and resistance: updated review of mechanisms, spread, influencing factors, and alternative approaches for combating resistance. Front Pharmacol. 2023;14:1305294. doi: 10.3389/fphar.2023.1305294. - DOI - PMC - PubMed
    1. Baquero F, Rodríguez-Beltrán J, Levin BR. Bacteriostatic cells instead of bacteriostatic antibiotics? mBio. 2024 Feb;15(2):e0268023. doi: 10.1128/mbio.02680-23. - DOI - PMC - PubMed
    1. Zheng EJ, Valeri JA, Andrews IW, Krishnan A, Bandyopadhyay P, Anahtar MN, Herneisen A, Schulte F, Linnehan B, Wong F, Stokes JM, Renner LD, Lourido S, Collins JJ. Discovery of antibiotics that selectively kill metabolically dormant bacteria. Cell Chem Biol. 2024 Apr;31(4):712–728. doi: 10.1016/j.chembiol.2023.10.026. - DOI - PMC - PubMed
    1. Zhang T, Liu Q, Meng F, Hou Y, Leung MKH, Wen Y, Zhang Q. Recent advances in stimuli-responsive antibacterial coatings: Bacteria-killing and releasing mechanism, design strategies, and potential applications. Prog Org Coat. 2024;186:107923. doi: 10.1016/j.porgcoat.2023.107923. - DOI
    1. Halawa EM, Fadel M, Al-Rabia MW, Behairy A, Nouh NA, Abdo M, Olga R, Fericean L, Atwa AM, El-Nablaway M, Abdeen A. Antibiotic action and resistance: updated review of mechanisms, spread, influencing factors, and alternative approaches for combating resistance. Front Pharmacol. 2023;14:1305294. doi: 10.3389/fphar.2023.1305294. - DOI - PMC - PubMed

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