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Review
. 2024 Nov 12:17:977-989.
doi: 10.2147/OTT.S496403. eCollection 2024.

Mechanisms of Action of HSP110 and Its Cognate Family Members in Carcinogenesis

Rongqi Guo #  1   2 , Rui Wang #  1   2 , Weisong Zhang  1   2 , Yangyang Li  1   2 , Yihao Wang  1   2 , Hao Wang  1   2 , Xia Li  3 , Jianxiang Song  1   2
Affiliations
Review

Mechanisms of Action of HSP110 and Its Cognate Family Members in Carcinogenesis

Rongqi Guo et al. Onco Targets Ther. .

Abstract

Tumors, as chronic malignant diseases that account for about 20% of all deaths worldwide, are the number one threat to human health. Until now there is no reliable treatment for most types of tumors. Tumorigenesis and cellular carcinogenesis remain difficult challenges due to their complex etiology and unknown mechanisms. As stress process regulating molecules and protein folding promoters, heat shock proteins (HSPs) play an important role in cancer development. Most studies have shown that HSPs are one of the major anticancer drug targets. HSPs are not only modulators of the cellular stress response, but are also closely associated with tumor initiation, progression, and drug resistance, so understanding the mechanism of the HSP family involved in cellular carcinogenesis is an important part of understanding tumorigenesis and enabling anticancer drug development. In this review, we discuss the functions and mechanisms of key members of the HSP family (HSP70, HSP90, and HSP110) in participating in the process of tumorigenesis and cell carcinogenesis, and look forward to the prospect of key members of the HSP family in targeted cancer therapy.

Keywords: HSP110; HSP70; HSP90; cancer; mechanisms.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Pathway mechanisms of HSP110 in cancer. Created with BioRender.com.
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