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Review
. 2024 Nov 14;18(6):061502.
doi: 10.1063/5.0228447. eCollection 2024 Dec.

Applications of microfluidics in mRNA vaccine development: A review

Affiliations
Review

Applications of microfluidics in mRNA vaccine development: A review

Ali Fardoost et al. Biomicrofluidics. .

Abstract

The transformative potential of microfluidics in the development of mRNA vaccines is explored in this review, highlighting its pivotal role in enhancing easy-to-use functionality, efficacy, and production efficiency. Moreover, we examine the innovative applications of microfluidics in biomedical research, including its contribution to the rapid and cost-effective synthesis of lipid nanoparticles for mRNA delivery and delve into the advantages of mRNA vaccines, such as targeted delivery and controlled expression. Furthermore, it outlines the future prospects of microfluidic devices, their cutting-edge examples in both research and industry, and the potential to revolutionize vaccine formulation and production. The integration of microfluidics with mRNA vaccine development represents a significant advancement in public health and disease prevention strategies.

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Conflict of interest statement

The authors have no conflicts to disclose.

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References

    1. Lopes C., Cristóvão J., Silvério V., Lino P. R., and Fonte P., “Microfluidic production of mRNA-loaded lipid nanoparticles for vaccine applications,” Expert Opin. Drug Delivery 19(10), 1381–1395 (2022). 10.1080/17425247.2022.2135502 - DOI - PubMed
    1. Viola J., Rafael D., Wagner E., Besch R., and Ogris M., “Gene therapy for advanced melanoma: Selective targeting and therapeutic nucleic acids,” J. Drug Delivery 2013, 897348 (2013). 10.1155/2013/897348 - DOI - PMC - PubMed
    1. Jacob F. and Monod J., “Genetic regulatory mechanisms in the synthesis of proteins,” J. Mol. Biol. 3(3), 318–356 (1961). 10.1016/S0022-2836(61)80072-7 - DOI - PubMed
    1. Brenner S., Jacob F., and Meselson M., “An unstable intermediate carrying information from genes to ribosomes for protein synthesis,” Nature 190, 576–581 (1961). 10.1038/190576a0 - DOI - PubMed
    1. Sharp P. A., “Split genes and RNA splicing (nobel lecture),” Angew. Chem., Int. Ed. Engl. 33(12), 1229–1240 (1994). 10.1002/anie.199412291 - DOI