It's About Time! Timing in Epilepsy Evaluation and Treatment

Heather Ravvin McKee¹, Jorge Vidaurre², Dave Clarke³, Janelle Wagner⁴, Jeffrey W Britton⁵, Linda Laux^{6

7}, Eugen Trinka⁸, Clio Rubinos⁹, Tanya J W McDonald¹⁰, Fred A Lado¹¹, Martina Bebin¹², Christos Papadelis¹³, Aaron F Struck^{14

15}, Carolina B Maciel¹⁶, Ana L Velasco^{17

18}, Arjun Chandran¹⁹, Sandipan Pati²⁰, Nitin Tandon¹⁹, Guadalupe Fernandez-Baca Vaca^{21

22}, Madison M Berl²³, Ahsan N Moosa²⁴

Affiliations

¹ Neurology, University of Cincinnati Medical Center, Cincinnati, OH, USA.
² EEG Laboratory, Nationwide Children's Hospital, Columbus, OH, USA.
³ Neurology, The University of Texas at Austin Dell Medical School, Austin, TX, USA.
⁴ College of Nursing, Medical University of South Carolina, Charleston, SC, USA.
⁵ Neurology, Mayo Clinic, Rochester, MN, USA.
⁶ Neurology, Ann & Robert H Lurie Children's Hospital of Chicago, Chicago, IL, USA.
⁷ Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
⁸ Department of Neurology, Christian Doppler Klinik, Paracelsus Medical University and Centre for Cognitive Neuroscience, Salzburg, Austria.
⁹ Neurology, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
¹⁰ Neurology, Johns Hopkins Medicine, Baltimore, MD, USA.
¹¹ Neurology, Northwell Health, Great Neck, NY, USA.
¹² Neurology, The University of Alabama at Birmingham, Birmingham, AL, USA.
¹³ Neuroscience Research Center, Jane and John Justin Institute for Mind Health, Cook Children's Health Care System, Fort Worth, TX, USA.
¹⁴ Neurology, University of Wisconsin-Madison, Madison, WI, USA.
¹⁵ Neurology, William S. Middleton Memorial Veterans Hospital, Madison, WI, USA.
¹⁶ Neurology, University of Florida College of Medicine, Gainesville, FL, USA.
¹⁷ Neurology, National Autonomous University of Mexico Medical Sciences, Ciudad de Mexico, Mexico.
¹⁸ Neurology, Epilepsy Clinic, Functional Neurosurgery, General Hospital of Mexico, Ciudad de Mexico, Mexico.
¹⁹ Neurosurgery, University of Texas McGovern Medical School, Houston, TX, USA.
²⁰ Neurology, University of Texas McGovern Medical School, Houston, TX, USA.
²¹ Neurology, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.
²² Neurology, Case Western Reserve University, Cleveland, OH, USA.
²³ Department of Psychiatry and Behavioral Sciences, The George Washington University School of Medicine and Health Sciences, Children's National Hospital, Washington, DC, USA.
²⁴ Neurology, Cleveland Clinic Children's Hospital, Cleveland, OH, USA.

PMID: 39554272
PMCID: PMC11561932
DOI: 10.1177/15357597241238072

Review

It's About Time! Timing in Epilepsy Evaluation and Treatment

Heather Ravvin McKee et al. Epilepsy Curr. 2024.

. 2024 Apr 1:15357597241238072.

doi: 10.1177/15357597241238072. Online ahead of print.

Authors

Affiliations

¹ Neurology, University of Cincinnati Medical Center, Cincinnati, OH, USA.
² EEG Laboratory, Nationwide Children's Hospital, Columbus, OH, USA.
³ Neurology, The University of Texas at Austin Dell Medical School, Austin, TX, USA.
⁴ College of Nursing, Medical University of South Carolina, Charleston, SC, USA.
⁵ Neurology, Mayo Clinic, Rochester, MN, USA.
⁶ Neurology, Ann & Robert H Lurie Children's Hospital of Chicago, Chicago, IL, USA.
⁷ Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
⁸ Department of Neurology, Christian Doppler Klinik, Paracelsus Medical University and Centre for Cognitive Neuroscience, Salzburg, Austria.
⁹ Neurology, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
¹⁰ Neurology, Johns Hopkins Medicine, Baltimore, MD, USA.
¹¹ Neurology, Northwell Health, Great Neck, NY, USA.
¹² Neurology, The University of Alabama at Birmingham, Birmingham, AL, USA.
¹³ Neuroscience Research Center, Jane and John Justin Institute for Mind Health, Cook Children's Health Care System, Fort Worth, TX, USA.
¹⁴ Neurology, University of Wisconsin-Madison, Madison, WI, USA.
¹⁵ Neurology, William S. Middleton Memorial Veterans Hospital, Madison, WI, USA.
¹⁶ Neurology, University of Florida College of Medicine, Gainesville, FL, USA.
¹⁷ Neurology, National Autonomous University of Mexico Medical Sciences, Ciudad de Mexico, Mexico.
¹⁸ Neurology, Epilepsy Clinic, Functional Neurosurgery, General Hospital of Mexico, Ciudad de Mexico, Mexico.
¹⁹ Neurosurgery, University of Texas McGovern Medical School, Houston, TX, USA.
²⁰ Neurology, University of Texas McGovern Medical School, Houston, TX, USA.
²¹ Neurology, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.
²² Neurology, Case Western Reserve University, Cleveland, OH, USA.
²³ Department of Psychiatry and Behavioral Sciences, The George Washington University School of Medicine and Health Sciences, Children's National Hospital, Washington, DC, USA.
²⁴ Neurology, Cleveland Clinic Children's Hospital, Cleveland, OH, USA.

PMID: 39554272
PMCID: PMC11561932
DOI: 10.1177/15357597241238072

Abstract

The 2023 American Epilepsy Society Annual Course "It's About Time" addressed timing in epilepsy evaluation and treatment with respect to health disparity and vulnerable populations and diagnostic, clinical, and epilepsy surgery evaluation. This comprehensive course included topics on gaps in epilepsy care and optimization of behavioral health for patients with epilepsy. The summary details current knowledge in areas of seizure forecasting and epileptogenesis. Intricacies and controversies over timing were discussed for treatment of nonconvulsive seizures and ictal-interictal patterns, acute symptomatic seizures, neuromodulation versus surgery, and epilepsy surgery in status epilepticus. Timing regarding clinical care in autoimmune-associated epilepsy, developmental and epileptic encephalopathy, and dietary therapy were examined. Additionally, salient topics on using novel biomarkers and collaboration with neuropsychological outcomes were also tackled in this all-encompassing lecture series.

Keywords: AES; annual course; behavioral health; disparities; epilepsy; ictal-interictal continuum; ketogenic diet therapy; seizure; time; timing.

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Conflict of interest statement

The author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article. DC reports funding from Neurelis Pharmaceuticals for consultation. ET reports personal fees from EVER Pharma, Marinus, Arvelle, Angelini, Argenx, Medtronic, Biocodex Bial-Portela & Ca, NewBridge, GL Pharma, GlaxoSmithKline, Boehringer Ingelheim, LivaNova, Eisai, Epilog, UCB, Biogen, Sanofi, Jazz Pharmaceuticals, and Actavis. His institution received grants from Biogen, UCB Pharma, Eisai, Red Bull, Merck, Bayer, the European Union, FWF Osterreichischer Fond zur Wissenschaftsforderung, Bundesministerium fu¨r Wissenschaft und Forschung, and Jubiläumsfond der Österreichischen Nationalbank. CR received speaker fees from Marinus for education content development, consulting fees from Quattro Consulting, and consulting fees from Azurity Pharmaceutical for advisory committee.

References

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It's About Time! Timing in Epilepsy Evaluation and Treatment

Affiliations

It's About Time! Timing in Epilepsy Evaluation and Treatment

Authors

Affiliations

Abstract

Conflict of interest statement

References

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