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. 2025 Mar;47(3):983-989.
doi: 10.1002/hed.27998. Epub 2024 Nov 18.

Outcome Analysis of Solitary Extramedullary Plasmacytoma in the Head and Neck: A Clinical Perspective

Po-Wen Chuang  1 , Wen-Yu Chuang  2 , Ta-Jen Lee  1   3 , Po-Hung Chang  1   4 , Yi-Wei Chen  1 , Chia-Hsiang Fu  1   4
Affiliations

Outcome Analysis of Solitary Extramedullary Plasmacytoma in the Head and Neck: A Clinical Perspective

Po-Wen Chuang et al. Head Neck. 2025 Mar.

Abstract

Introduction: Solitary extramedullary plasmacytomas (SEP) of the head and neck are rare and pose unique challenges. This study aimed to explore the clinical spectrum and treatment outcomes of these neoplasms using multimodal management.

Methods: A retrospective review of 13 patients with SEP of the head and neck. Data on demographics, clinical presentation, diagnostics, treatment, and survival outcomes were analyzed.

Results: One patient refused the treatment and was lost to follow-up. Another one received operation alone. The other 11 patients underwent surgical resection when feasible and showed favorable responses to radiation. Two of them (16.7%) experienced local recurrence, and another two patients (16.7%) progressed to multiple myeloma (MM) within the first 2 years following the initial treatment. Tumor > 2.6 cm significantly affected the post-radiation prognosis.

Conclusion: Although radiotherapy yields favorable immediate outcomes in our limited case series, a subset of cases progresses to MM within the initial 2 years. Despite all tumors being categorized as Stage I, tumor size may still influence prognosis.

Keywords: head and neck; multiple myeloma; plasmacytoma; solitary extramedullary plasmacytoma.

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References

    1. S. Kilciksiz, O. Karakoyun‐Celik, F. Y. Agaoglu, and A. Haydaroglu, “A Review for Solitary Plasmacytoma of Bone and Extramedullary Plasmacytoma,” ScientificWorld Journal 2012 (2012): 895765.
    1. T. D. Ellington, S. J. Henley, R. J. Wilson, M. Wu, and L. C. Richardson, “Trends in Solitary Plasmacytoma, Extramedullary Plasmacytoma, and Plasma Cell Myeloma Incidence and Myeloma Mortality by Racial‐Ethnic Group, United States 2003–2016,” Cancer Medicine 10, no. 1 (2021): 386–395.
    1. A. Pham and A. Mahindra, “Solitary Plasmacytoma: A Review of Diagnosis and Management,” Current Hematologic Malignancy Reports 14, no. 2 (2019): 63–69.
    1. A. Holler, I. Cicha, M. Eckstein, et al., “Extramedullary Plasmacytoma: Tumor Occurrence and Therapeutic Concepts‐A Follow‐Up,” Cancer Medicine 11, no. 24 (2022): 4743–4755.
    1. G. Bachar, D. Goldstein, D. Brown, et al., “Solitary Extramedullary Plasmacytoma of the Head and Neck – Long‐Term Outcome Analysis of 68 Cases,” Head & Neck 30, no. 8 (2008): 1012–1019.

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