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Review
. 2024 Dec 31;25(1):2425131.
doi: 10.1080/15384047.2024.2425131. Epub 2024 Nov 18.

Tumor microenvironment in primary central nervous system lymphoma (PCNSL)

Qiqi Jin  1 , Haoyun Jiang  1 , Ye Han  1 , Litian Zhang  1 , Cuicui Li  1 , Yurong Zhang  1 , Ye Chai  1 , Pengyun Zeng  1 , Lingling Yue  1 , Chongyang Wu  1
Affiliations
Review

Tumor microenvironment in primary central nervous system lymphoma (PCNSL)

Qiqi Jin et al. Cancer Biol Ther. .

Abstract

Primary central nervous system lymphoma (PCNSL) is one of the rare lymphomas limited to the central nervous system. With the availability of immunotherapy, the tumor microenvironment (TME) attracts much attention nowadays. However, the systematic studies on the TME of PCNSL are lacking. By reviewing the existing research, we found that the TME of PCNSL is infiltrated with abundant TAMs and TILs, among which cytotoxic T cells (CTLs) and M2-polarized macrophages are principal. However, the counts of immune cells infiltrated in the TME of PCNSL are significantly lower than systemic diffuse large B-cell lymphoma (DLBCL). In addition, PCNSL can attract the infiltration of immunosuppressive cells and the loss of HLA I/II expression, overexpress inhibitory immune checkpoints, and release immunosuppressive cytokines to form an immunosuppressive TME. The immunosuppressive effect of TME in PCNSL is significantly stronger than that in systemic DLBCL. These characteristics of TME highlight the immunosuppression of PCNSL.

Keywords: IL-10; MDSCs; PCNSL; PD-1/PD-L1; TAMs; TILs; TME; Tregs.

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Conflict of interest statement

No potential conflict of interest was reported by the author(s).

Figures

The composition of TME can be divided into pro-tumor growth and anti-tumor growth, and it is tends to promote tumor growth in PCNSL.
Figure 1.
Tumor microenvironment of PCNSL. The figure materials come from Servier Medical Art (http://smart.servier.com/) and it is licensed under a creative common attribution 3.0 generic license (https://creativecommons.Org/licenses/by/3.0/).
See this image and copyright information in PMC

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