A review on the potential use of bismuth nanoparticles in oral health

Abstract

According to many investigations, persistent oral infections may be caused by oral pathogenic biofilms. Irritation of soft tissues and subsequent bone resorption due to bacterial biofilm contamination of the implant further worsen oral health. Dental problems may be effectively treated using metal nanoparticles (NPs) because they limit the development of many different types of bacteria. With their low toxicity, X-ray sensitivity, high atomic number, near-infrared driven semiconductor qualities, and cheap cost, multifunctional bismuth (Bi) NPs with therapeutic activities show significant potential for the domains of bacterial infection diagnostics and treatment. Also, by directly communicating with the bacterial cell wall, stimulating intracellular effects, inhibiting biofilm formation, producing reactive oxygen species, and inducing adaptive and innate immune responses, BiNPs offer an alternative to conventional antibiotics for treating bacteria with multiple drug resistance (MDR). Hence, BiNPs, which have more antibacterial activity and fewer side effects than chlorhexidine, might be a promising option to fight biofilm-forming bacteria in the mouth. This could lead to their usage in several areas of dentistry. The research delves into the many synthesis techniques of BiNPs and their antibacterial and anticancer capabilities. Next, we'll review how this nanoparticle has helped with dental infections, periodontitis, and dental implant problems. The anticancer effects of BiNPs on oral cancer were also studied. Thus, after this paper, we have highlighted the therapeutic limits and ways to address this issue for the clinical success of BiNPs in promoting oral and dental health.

Keywords: Antibacterial; Anticancer; Bismuth nanoparticle; Dental infection; Oral cancer; Periodontitis.