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. 2025 Feb;63(2):151-154.
doi: 10.1002/mrc.5496. Epub 2024 Nov 18.

Structural Elucidation and NMR Spectral Assignments of New Diphenyl Ether Derivatives From Liuweizhiji Gegen-Sangshen Oral Liquid

Jinghao Cui  1 , Xin Zhou  2 , Baorui Teng  1 , Dan Zhang  1 , Xiujuan Fu  1 , Siwei Chen  1 , Sijing Liu  3 , Zhi Li  2 , Hui Lei  1
Affiliations

Structural Elucidation and NMR Spectral Assignments of New Diphenyl Ether Derivatives From Liuweizhiji Gegen-Sangshen Oral Liquid

Jinghao Cui et al. Magn Reson Chem. 2025 Feb.

Abstract

Chemical investigation of the Liuweizhiji Gegen-Sangshen oral liquid afforded one new diphenyl ether derivative (1), together with one known compound (2). Their structures were established by 1D and 2D NMR, and HR-ESI-MS spectroscopic analysis and the absolute configuration of 1 was confirmed by ECD calculation. Compounds 1 and 2 were evaluated for the cytotoxic activities, and compounds 1 and 2 showed weak cytotoxic activities towards HepG2 human liver cancer cells, with IC50 values of 97.3 and 79.6 μM, respectively.

Keywords: Liuweizhiji Gegen‐Sangshen oral liquid; NMR spectra; diphenyl ether derivatives; identification; structural elucidation.

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