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Observational Study
. 2024 Nov 19;184(1):28.
doi: 10.1007/s00431-024-05827-6.

Muscle strength, functional mobility, and performance in activities of daily living in children and adolescents with cancer

Raiane Marques Furtado Barbosa  1 , Priscilla Faria Goretti  1 , Paula Silva de Carvalho Chagas  2
Affiliations
Observational Study

Muscle strength, functional mobility, and performance in activities of daily living in children and adolescents with cancer

Raiane Marques Furtado Barbosa et al. Eur J Pediatr. .

Abstract

During and after childhood cancer treatment, impairments in physical fitness are observed, such as reduced muscle strength, fatigue, and changes in body functions. These aspects may result in limitations and restrictions in performance of daily activities. To analyze the relationship between upper and lower limb muscle strength, functional mobility, and performance in activities daily living in children, adolescents, and young adults with cancer, compared to their healthy peers. The cross-sectional observational study involves 45 participants, 15 in the cancer group and 30 in the control group. Personal, environmental, and health data were collected. Participants from both groups were evaluated for upper and lower limb muscle strength, functional mobility (timed up and go test-TUG and five times sit-to-Stand test-5xSTS), and performance in activities of daily living (Pediatric Evaluation Of Disability Inventory-Computer Adaptive Test-PEDI-CAT). The participants were 30 females and 15 males (13.67 ± 5.78 years: cancer group; 13.07 ± 5.11 years: control group). Acute lymphoblastic leukemia (n = 7), chronic myeloid leukemia (n = 2) and Hodgkin's lymphoma (n=2) were the main diagnoses in the cancer group. No significant differences were found in upper and lower limb muscle strength between groups (p > 0.05). However, significant differences were observed in functional mobility (TUG and 5xSTS) and performance (PEDI-CAT-mobility) in activities of daily living, with the cancer group showing worse performance compared to the control group (p ≤ 0.001). Conclusion: Children and adolescents with cancer showed lower functional mobility and performance in activities of daily living compared to the control group. These difficulties were not associated with muscle weakness or level of physical activity. Therefore, it is recommended that physiotherapeutic treatment and follow-up include activities focused on mobility and functional independence.

Keywords: Cancer; Functioning; Muscle strength; Physical activity.

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Conflict of interest statement

Declarations During the preparation of this work, AI tools were used to improve the readability and language of the manuscript, and subsequently, the authors revised and edited the content produced by the AI tools as necessary taking full responsibility for the ultimate content of the present manuscript. Ethical approval and consent to participate The study was approved by the Research Ethics Committee of Universidade Federal de Juiz de Fora under opinion no. 28699920.2.0000.5147, in accordance with the Declaration of Helsinki. All participants that agreed to participate signed the informed consent term. Competing interests The authors declare no competing interests.

References

    1. INCA (2023) Estimate 2023: incidence of cancer in Brazil. Rio de Janeiro: Instituto Nacional do Cancer José Alencar Gomes da Silva. Available at: https://www.inca.gov.br/publicacoes/livros/estimativa-2023-incidencia-de... . Accessed 11 Aug 2024
    1. Jochem C, Leitzmann M, Volaklis K, Aune D, Strasser B (2019) Association between muscular strength and mortality in clinical populations: a systematic review and meta-analysis. J Am Med Dir Assoc 20(10):1213–1223 - DOI - PubMed
    1. Amakye WK, Zhang Z, Wei Y, Shivappa N, Hebert JR, Wang J et al (2018) The relationship between dietary inflammatory index (DII) and muscle mass and strength in Chinese children aged 6–9 years. Asia Pac J Clin Nutr 27(6):1315–1324 - PubMed
    1. Wurz A, McLaughlin E, Lategan C, Chamorro Vina C, Grimshaw SL, Hamari L et al (2021) The international Pediatric Oncology Exercise Guidelines (iPOEG). Transl Behav Med 11(10):1915–1922 - DOI - PubMed - PMC
    1. WHO (2001) International classification of functioning, disability and health (ICF). Geneva: WHO Library, p 315

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