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. 2025 Jan 6;53(D1):D56-D61.
doi: 10.1093/nar/gkae1114.

GenBank 2025 update

Eric W Sayers  1 , Mark Cavanaugh  1 , Linda Frisse  1 , Kim D Pruitt  1 , Valerie A Schneider  1 , Beverly A Underwood  1 , Linda Yankie  1 , Ilene Karsch-Mizrachi  1
Affiliations

GenBank 2025 update

Eric W Sayers et al. Nucleic Acids Res. .

Abstract

GenBank® (https://www.ncbi.nlm.nih.gov/genbank/) is a comprehensive, public data repository that contains 34 trillion base pairs from over 4.7 billion nucleotide sequences for 581 000 formally described species. Daily data exchange with the European Nucleotide Archive and the DNA Data Bank of Japan ensures worldwide coverage. We summarize the content of the database in 2025 and recent updates such as accelerated processing of influenza sequences and the ability to upload feature tables to Submission Portal for messenger RNA sequences. We provide an overview of the web, application programming and command-line interfaces that allow users to access GenBank data. We also discuss the importance of creating BioProject and BioSample records during submissions, particularly for viruses and metagenomes. Finally, we summarize educational materials and recent community outreach efforts.

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Figures

Graphical Abstract
Graphical Abstract
Figure 1.
Figure 1.
Growth of GenBank recorded in both base pairs (circles) and the number of sequence records (triangles). Each point represents the GenBank release in August of each year, starting with release 173 (August 2009).
Figure 2.
Figure 2.
Taxonomy page in NCBI Datasets for the family Suidae providing easy access to available genomes, nucleotide and protein sequences, SRA data, BioProjects and more, in addition to the other taxonomic nodes in the lineage of Suidae.
See this image and copyright information in PMC

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