Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Oct 17;16(10):e71734.
doi: 10.7759/cureus.71734. eCollection 2024 Oct.

Relationship Between Osteoarthritis and Postmenopausal Osteoporosis: An Analysis Based on the National Health and Nutrition Examination Survey

Zheyu Fang  1 , Jiaxin Zhao  2 , Yuan Zhang  1 , Xin Hua  1 , Jia Li  1 , Xu Zhang  1
Affiliations

Relationship Between Osteoarthritis and Postmenopausal Osteoporosis: An Analysis Based on the National Health and Nutrition Examination Survey

Zheyu Fang et al. Cureus. .

Abstract

Introduction Due to the increased prevalence of osteoarthritis (OA) and osteoporosis (OP) in women, urgent interventions are needed to reduce the risk of postmenopausal fractures in female OA patients. Moreover, the relationship between OA and OP remains contentious, emphasizing the need for further research to deepen our understanding. This study aimed to investigate the relationship between OA and postmenopausal OP using data from the National Health and Nutrition Examination Survey (NHANES). Methods We conducted a cross-sectional analysis using NHANES summary data from 2005 to 2010, 2013 to 2014, and 2017 to 2020. Multivariable logistic regression was employed to evaluate the association between OA and the risk of postmenopausal OP. Adjustments were made for potential confounding factors. Additionally, we conducted stratified analyses, which provided further insights into the association between OA and postmenopausal OP across various subgroups. Results The analysis revealed a significant correlation between OA and an increased risk of postmenopausal OP, with an odds ratio (OR) of 1.12 (95% confidence interval (CI): 1.07-1.17, P < 0.001) after adjusting for confounders. Stratified analyses revealed a significant association between OA and postmenopausal OP in obese and overweight individuals (OR 1.14, 95% CI 1.06-1.22, P < 0.001; OR 1.18, 95% CI 1.04-1.32, P = 0.008) and among former or current smokers (OR 1.20, 95% CI 1.08-1.33, P < 0.001). Conclusions The study underscores a significant association between OA and postmenopausal OP, particularly in obese, overweight, and smoking populations. Given the higher prevalence of OA and OP among women, understanding these associations could lead to improved strategies for reducing postmenopausal fracture risks. The study offers valuable insights and potential directions for future therapeutic approaches.

Keywords: nhanes; osteoarthritis; postmenopausal osteoporosis; stratified analyses; women.

PubMed Disclaimer

Conflict of interest statement

Human subjects: Consent was obtained or waived by all participants in this study. The Institutional Review Board of the National Center for Health Statistics issued approval #2005-06, #2011-17, and #2018-01. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Figures

Figure 1
Figure 1. Screening procedure of study subjects
NHANES: National Health and Nutrition Examination Survey
Figure 2
Figure 2. Associations between OA and postmenopausal osteoporosis based on BMI, age, and smoking status
Logistic regression analysis *: statistically significant result (P < 0.05) BMI: body mass index; OR: odds ratio; CI: confidence interval; OA: osteoarthritis
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Drug therapy for osteoporosis in older adults. Reid IR, Billington EO. Lancet. 2022;399:1080–1092. - PubMed
    1. Epidemiology, etiology, and diagnosis of osteoporosis. Lane NE. Am J Obstet Gynecol. 2006;194:0–11. - PubMed
    1. Immunoporosis: role of immune system in the pathophysiology of different types of osteoporosis. Zhang W, Gao R, Rong X, Zhu S, Cui Y, Liu H, Li M. Front Endocrinol (Lausanne) 2022;13:965258. - PMC - PubMed
    1. Postmenopausal osteoporosis. Walker MD, Shane E. N Engl J Med. 2023;389:1979–1991. - PubMed
    1. T-cell mediated inflammation in postmenopausal osteoporosis. Wu D, Cline-Smith A, Shashkova E, Perla A, Katyal A, Aurora R. Front Immunol. 2021;12:687551. - PMC - PubMed

LinkOut - more resources