Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024:40:545-576.
doi: 10.1007/978-3-031-69491-2_19.

EEG Biomarkers for Autism: Rational, Support, and the Qualification Process

Caitlin M Hudac  1   2 , Sara Jane Webb  3   4
Affiliations
Review

EEG Biomarkers for Autism: Rational, Support, and the Qualification Process

Caitlin M Hudac et al. Adv Neurobiol. 2024.

Abstract

In this chapter, we highlight the advantages, progress, and pending challenges of developing electroencephalography (EEG) and event-related potential (ERP) biomarkers for use in autism spectrum disorder (ASD). We describe reasons why global efforts towards precision treatment in ASD are utilizing EEG indices to quantify biological mechanisms. We overview common sensory processing and attention biomarkers and provide translational examples examining the genetic etiology of autism across animal models and human subgroups. We describe human-specific social biomarkers related to face perception, a complex social cognitive process that may prove informative of autistic social behaviors. Lastly, we discuss outstanding considerations for quantifying EEG biomarkers, the challenges associated with rigor and reproducibility, contexts of future use, and propose opportunities for combinatory multidimensional biomarkers.

Keywords: Biomarkers of autism spectrum disorder (ASD); Electroencephalography (EEG); Event-related potentials (ERP); Face perception; Sensory processing.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Allen G, Courchesne E. Attention function and dysfunction in autism. Frontiers in Bioscience-Landmark. 2001;6(1):D105–19. https://doi.org/10.2741/allen . - DOI
    1. Anzures G, Goyet L, Ganea N, Johnson MH. Enhanced ERPs to visual stimuli in unaffected male siblings of ASD children. Child Neuropsychol. 2016;22(2):220–37. https://doi.org/10.1080/09297049.2014.988609 . - DOI - PubMed
    1. Arnett AB, Hudac CM, DesChamps TD, Cairney BE, Gerdts J, Wallace AS, Bernier RA, Webb SJ. Auditory perception is associated with implicit language learning and receptive language ability in autism spectrum disorder. Brain Lang. 2018;187(Autism Research 9 8 2016):1. https://doi.org/10.1016/j.bandl.2018.09.007 . - DOI - PubMed - PMC
    1. Balasco L, Provenzano G, Bozzi Y. Sensory abnormalities in autism Spectrum disorders: a focus on the tactile domain, from genetic mouse models to the clinic. Front Psych. 2020;10:1016. https://doi.org/10.3389/fpsyt.2019.01016 . - DOI
    1. Bentin S, Allison T, Puce A, Perez E, McCarthy G. Electrophysiological studies of face perception in humans. J Cogn Neurosci. 1996;8(6):551–65. - DOI - PubMed - PMC