Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Nov 19;14(1):28656.
doi: 10.1038/s41598-024-78405-3.

Therapeutic and antioxidant properties of Acridocarpus monodii Arène & Jaeger, an endemic plant of Dogon Country in Mali

Mamadou A Konaré  1 , Joudy Dougnon  2 , Issiaka Togola  2 , Nah Traoré  3 , Nouhoum Diarra  2 , Moussa Karembé  4
Affiliations

Therapeutic and antioxidant properties of Acridocarpus monodii Arène & Jaeger, an endemic plant of Dogon Country in Mali

Mamadou A Konaré et al. Sci Rep. .

Abstract

Acridocarpus monodii Arène & Jaeger is an endemic plant species to the ''Dogon Country'' in Mali. This species is highly popular in Dogon ethnic groups, but no scientific data on its medicinal and biochemical properties are available in Mali. This work aimed to list its medicinal uses and assess its phytochemical composition and antioxidant power. An ethnobotanical investigation based on semi structured questionnaire was used to identify the traditional uses of A. monodii among the local population in three villages (Ireli, Youdiou and Yon-biré) inside ''Dogon country'' in Mali. The phytochemical composition was determined using qualitative tests, while the antioxidant potency was performed using 2,2-diphenyl-1-picryhydazyl (DPPH) and phosphomolybdate (TAC) tests. A total of 45 people were interviewed, the majority of whom were male (82.20%) and over 52 years of age. A. monodii is used to treat a dozen pathologies or diseases, dominated by malaria (71.10%), yellow fever (24.40%) and dysuria (20%). Although, all parts of this species are used to treat these pathologies, leaves (88.90%) were the most coveted followed by roots (37.80%). The use of these parts was significantly (p = 0.016 < 0.05) associated with the educational levels of the respondents (77.70%), who coveted primarily roots and barks, and thus constituted a threat to the species. These medicinal recipes derived from these organs were mostly prepared as decoctions, before being administered by oral (100%) or bath (82.20%) routes. Extracts of A. monodii were found to contain various biocompounds, especially a high quantity of flavonoids and polyphenols and demonstrated increased in vitro antioxidant inhibitory effects. The decoction extracts showed the highest content of phenolic compounds (109.82 ± 2.36 mg GAE/g). The strongest activity for the DPPH free radical scavenging were recorded by the decoction with IC50 = 107.41 ± 4.25 µg/mL and the hydroethanolic macerate with 107.31 ± 9.28 µg/mL. But, based on the results from of TAC test, the antioxidant capacity was higher for the hydroethanolic macerate 42.85 ± 2.59 mg EQ/g than those of the decoction 19.27 ± 0.93 mg EQ/g. This is the first scientific report on the therapeutic use of A. monodii within ''Dogon country'' in Mali. This work highlights its medicinal, phytochemical and biochemical properties and therefore contributes to its improved valorization. These results demonstrated that A. monodii is a promising species for the discovery of novel medicines.

Keywords: A. monodii; Antioxidant potential; Dogon country; Phytochemical composition; Traditional uses.

PubMed Disclaimer

Conflict of interest statement

Declarations Competing interests The authors declare no competing interests. Consent to participate declaration The current work was undertaken in the framework of a preservation and valorization of local practices on A. monodii medicinal use by the population of ‘‘Dogon country’’, in Mali. This study has started after receiving formal agreement from the local authorities of Dogon Community. The protocol was approved by the local Ethic Committee of the Biology Department of the Faculty of Sciences and Techniques (FST) of the University of Sciences, Techniques and Technologies of Bamako (USTTB) in accordance with the International Ethnobiology Society’s ethical guidelines (ISE Code of Ethics) 5,28. All the participants received an explanation of the process and nature of this work and then were asked to provide oral informed consent. During data collection in each village, the cultural norms were respected. Likewise, the collection of the wild plant material used in our study complies with cultural and local guidelines.

Figures

Fig. 1
Fig. 1
Map of Mali showing study areas.
Fig. 2
Fig. 2
Frequencies of therapeutic uses of A. monodii by local population.
Fig. 3
Fig. 3
Repartitioning of organ use according to the sex of the respondents and the investigated villages. (A) Global distribution. (B) Specific distribution according to levels of education. (C) Specific distribution according to sex and village.
Fig. 4
Fig. 4
Preparation modes.
Fig. 5
Fig. 5
Administration routes.
See this image and copyright information in PMC

References

    1. Coppo, P., Keita, A. Médecine traditionnelle, acteurs, itinéraires thérapeutiques. Ed E, Trieste. (1990).
    1. Cissé, L. Patrimoine et développement local—le rôle des collectivités territoriales dans la gestion du site des falaises de Bandiagara (Mali). Icomos PAris. 221–9 (2011).
    1. Birnbaum, P., Florence, J. Validation d’Acridocarpus monodii Arènes & Jaeger ex Birnbaum & J. Florence, sp. nov. (Malpighiaceae). Notes sur sa biologie. Adansonia, Sér 3- Publ Sci du Musém Natl d’Histoire Nat. Paris. 27(2), 235–41 (2005).
    1. Davis, C. C. & Anderson, W. R. A complete generic phylogeny of Malpighiaceae inferred from nucleotide sequence data and morphology. Am. J. Bot.97(12), 2031–2048 (2010). - PubMed
    1. van Andel, T. R. et al. Prioritizing West African medicinal plants for conservation and sustainable extraction studies based on market surveys and species distribution models. Biol. Conserv.181, 173–181. 10.1016/j.biocon.2014.11.015 (2015).

LinkOut - more resources