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. 2024 Nov 15;10(12):e1729.
doi: 10.1097/TXD.0000000000001729. eCollection 2024 Dec.

First Longitudinal Analysis of the Immunological Mechanism at Play in Uterus Transplantation

Marie Carbonnel  1   2   3 , Remy Villette  3 , Maxime Petit  4 , Nadine Tarantino  3 , Veronique Morin  3 , Angélique Vinit  4 , Emmanuel Roux  5 , Morgan Tourne  6 , Camélia Radulescu  6 , Zakhia El Beaino  6 , Mathilde Le Marchand  5 , Renaud Snanoudj  7 , Catherine Racowsky  1 , Martin Larsen  3 , Mats Brännström  8   9 , Jean-Marc Ayoubi  1   2 , Vincent Vieillard  3
Affiliations

First Longitudinal Analysis of the Immunological Mechanism at Play in Uterus Transplantation

Marie Carbonnel et al. Transplant Direct. .
No abstract available

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Figures

FIGURE 1.
FIGURE 1.
A, Clinical course of the UTx patient (PE and kidney failure; DSA+). B, Comparison of cervical biopsies from randomly selected healthy, nonpregnant controls and the UTx patient at 30 mo post-UTx and at UTx explantation, and a uterine fundus biopsy of the graft at explantation. Arrows shows C4d staining in vessels. Asma, alpha smooth muscle actin; CD4, T4 lymphocyte; CD8, T8 lymphocyte; CD20, B lymphocyte; CD68, macrophage; DSA, donor-specific antibody; PE, preeclampsia; UTx, uterus transplantation.
FIGURE 2.
FIGURE 2.
Kinetics of blood biological markers and the vaginal microbiome in the UTx patient vs healthy controls (n = 6). A, Frequency of CD27+ and CD38+ and B cells. B, Non–multidimensional scaling. C, Abundance of the top genes in the vaginal microbiome. Incidence of inflammatory cytokines and CRP (D), HLA-DR and NKG2C (E), CD107a among CD3−CD56+ NK cells with K567 (F), and CRP (G). Red arrow indicates delivery. CRP, C-reactive protein; IL, interleukin; NK, natural killer; TNF-α, tumor necrosis factor-α; UTx, uterus transplantation.
See this image and copyright information in PMC

References

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