Comparative Study
doi: 10.1007/BF01942514.
Effect of halogenmethylenebisphosphonates on bone cells in culture and on bone resorption in vivo
- PMID: 3956686
- DOI: 10.1007/BF01942514
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Comparative Study
Effect of halogenmethylenebisphosphonates on bone cells in culture and on bone resorption in vivo
Experientia.
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Abstract
Dihalogenmethylenebisphosphonates increase alkaline phosphatase activity and fatty acid oxidation in calvaria cells in culture (Cl2MBP greater than Br2MBP approximately equal to F2MBP). The monohalogen ClMBP and the non-halogenated analogues are less active on phosphatase and inactive on or inhibitory towards fatty acid oxidation. The three dihalogenbisphosphonates and ClMBP inhibit bone resorption in vivo, Cl2MBP most strongly.
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