Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2025 Jun;83(2):1465-1481.
doi: 10.1007/s12013-024-01617-x. Epub 2024 Nov 20.

Exosome-mediated Transfer of lncRNA in Liver Associated Diseases; Uncovered Truths

Raed Obaid Saleh  1 , Hamad Ali Hamad  2   3 , Maryam Abdulrahman Najim  4 , Soumya V Menon  5 , Mandeep Kaur  6 , G V Sivaprasad  7 , Mohammad Abohassan  8 , Wen-Tau Juan  9 , Beneen Husseen  10   11   12 , Yasser Fakri Mustafa  13
Affiliations
Review

Exosome-mediated Transfer of lncRNA in Liver Associated Diseases; Uncovered Truths

Raed Obaid Saleh et al. Cell Biochem Biophys. 2025 Jun.

Abstract

Exosomes are extracellular vesicles with a diameter ranging from 40 to 160 nm. They are produced by hepatocytes, cholangiocytes, hepatic stellate cells (HSCs), liver sinusoidal endothelial cells (LSECs) and Kupffer cells in liver tissue. The secretion of exosomes might vary in quantity and composition in reaction to multiple triggers and various stages of disease. They transport various payloads, such as proteins, DNAs, and RNAs, and enable cell interaction to regulate myriad physiological and pathological processes in liver tissue. Long non-coding RNAs (lncRNAs) are a crucial component of exosomes with an excellent capability to regulate multiple cellular activities such as differentiation, development, metabolism, proliferation, apoptosis, and activation. With the advancements in transcriptomic and genomic study methods and database management technology, the functions and mechanisms of exosomal lncRNAs in liver diseases have been well-studied. This article delves into the detailed role of exosomal lncRNAs in liver disease onset and progression, ranging from hepatocellular carcinoma (HCC) to liver fibrosis drug-induced liver damage (DILI) and steatotic liver diseases.

Keywords: Exosomes; Hepatocellular carcinoma; Liver fibrosis; Long non-coding RNAs; Pathogenesis.

PubMed Disclaimer

Conflict of interest statement

Compliance with Ethical Standards. Conflict of Interest: The authors declare no competing interests.

References

    1. Kudo, M. (2015). Chronic Liver Diseases and Liver Cancer: An Update in 2015. Digestive Diseases, 33(6), 705–7. - PubMed - DOI
    1. Maheshwari, A., & Thuluvath, P. J. (2011). Endocrine diseases and the liver. Clinics in Liver Disease, 15(1), 55–67. - PubMed - DOI
    1. Tajiri, K., & Shimizu, Y. (2013). Liver physiology and liver diseases in the elderly. World Journal of Gastroenterology, 19(46), 8459–67. - PubMed - PMC - DOI
    1. Vilstrup, H., Amodio, P., Bajaj, J., Cordoba, J., Ferenci, P., Mullen, K. D., & Weissenborn, K., et al. (2014). Hepatic encephalopathy in chronic liver disease: 2014 Practice Guideline by the American Association for the Study of Liver Diseases and the European Association for the Study of the Liver. Hepatology, 60(2), 715–35. - PubMed - DOI
    1. Aravalli, R. N., & Steer, C. J. (2018). CRISPR/Cas9 therapeutics for liver diseases. Journal of Cellular Biochemistry, 119(6), 4265–78. - PubMed - DOI

Substances

LinkOut - more resources