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Review
. 2024 Nov 15:17:4277-4286.
doi: 10.2147/DMSO.S470647. eCollection 2024.

Research Progress of Alternative Polyadenylation in Diseases Related to Glycolipid Metabolism

Xiyao Yang #  1 , Alayi Bolatai #  2 , Jiaxin An  2 , Na Wu  1   3
Affiliations
Review

Research Progress of Alternative Polyadenylation in Diseases Related to Glycolipid Metabolism

Xiyao Yang et al. Diabetes Metab Syndr Obes. .

Abstract

With changes in lifestyle, sedentary behavior or lack of physical exercise increases the risk of various glycolipid metabolic disorders. Glycolipid metabolic dysregulation refers to abnormalities in the metabolism of carbohydrates and lipids, including diseases such as diabetes, obesity, and metabolic syndrome. In-depth research into the molecular mechanisms of glycolipid metabolic dysregulation can help develop more effective treatment strategies and preventive measures to prevent the occurrence of long-term complications such as cardiovascular diseases. Alternative polyadenylation (APA) is an important form of RNA modification that helps regulate gene expression and generate protein diversity. This modification can affect processes such as RNA stability, post-transcriptional modification, and translational regulation. Recent studies have confirmed that APA can influence the expression of genes involved in glucose and lipid metabolism, increasing the probability of developing immune, endocrine, and metabolic diseases. The review explains the research progress of APA involvement in various metabolic diseases and explores these mechanisms, providing new insights and directions for novel metabolic disorder treatment strategies.

Keywords: 3’UTRs; APA; alternative polyadenylation; diabetes; dysfunction; glycolipid metabolic diseases; metabolism; obesity.

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Conflict of interest statement

The authors declare no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Changes in the number of articles on APA in the field of metabolism over the years.
Figure 2
Figure 2
Research progress of APA modification in metabolic diseases. By Figdraw.
See this image and copyright information in PMC

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