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. 2024 Oct 21;16(10):e72006.
doi: 10.7759/cureus.72006. eCollection 2024 Oct.

Disproportionately Increased Incidence of Anaplastic Thyroid Cancer in the North Yorkshire Region: A UK Tertiary Centre Study

Ayodeji Adedeji  1 , Eugene Omakobia  1 , Charles Ojo  2 , Andrew Coatesworth  1 , Frank Agada  1
Affiliations

Disproportionately Increased Incidence of Anaplastic Thyroid Cancer in the North Yorkshire Region: A UK Tertiary Centre Study

Ayodeji Adedeji et al. Cureus. .

Abstract

Globally, the incidence of anaplastic thyroid cancer (ATC) has followed a stable trend. However, over the past decade, we have observed a marked rise in the number of cases in the North Yorkshire region of the United Kingdom. Our study aimed to explore the incidence, demographics, and geographical distribution of ATC in this region over a 12-year period. We retrieved the clinical records of all patients with ATC in our centre from 2010 to 2022 and determined the incidence, demographics, and geographical spread of the data. 20 patients were diagnosed with ATC within the data collection period, with an average annual incidence of 14 per 10,000,000 of the entire North Yorkshire population (35 per 10,000,000 age-adjusted incidence rate). There was a clustering of data around the North Yorkshire region centre. The incidence of ATC in North Yorkshire was geometrically higher than the national average of 1.7 per 10,000,000. The geographical clustering around the region's centre was likely explained by its higher population density.

Keywords: anaplastic; cancer; dysphagia; head and neck surgery; neck lump; north yorkshire; thyroid; united kingdom.

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Conflict of interest statement

Human subjects: Consent for treatment and open access publication was obtained or waived by all participants in this study. Ethics committee of York Teaching Hospital issued approval (exempt). Since this was a retrospective study of patient case records with no alteration in interventions received by the patients nor involvement in clinical trials, approval with the exemption of patient consent was granted by the ethics committee of York Teaching Hospital. . Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Figures

Figure 1
Figure 1. Geographical distribution indicating the incidence of anaplastic thyroid cancer cases in the North Yorkshire region of the United Kingdom between years 2010 and 2022
Y: York; HG: Harrogate; E: Easingwold; SC: Scarborough; SB: Stamford Bridge; S: Selby; P: Pickering; BR: Bridlington; M: Malton Adapted from https://www.plumplot.co.uk/North-Yorkshire-population.html [8]. Contains public sector information licensed under the Open Government Licence v3.0. This image has been created by the authors on Microsoft Excel (Microsoft Corp., Redmond, WA).
Figure 2
Figure 2. Distribution of population age groups in North Yorkshire compared to corresponding data in England and Wales, 2020
Reproduced from https://www.plumplot.co.uk/North-Yorkshire-population.html [8]. Contains public sector information licensed under the Open Government Licence v3.0.
See this image and copyright information in PMC

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