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Randomized Controlled Trial
. 2025 Mar;26(3):382-389.
doi: 10.1111/hiv.13741. Epub 2024 Nov 21.

High prevalence of osteoporosis among virally suppressed older people (≥60 years) living with HIV

Jeremy Penner  1   2 , Loice A Ombajo  1   3 , Joseph Nkuranga  1   3 , Edwin Otieno  1   3 , Diana Nyakoe  4 , Ruth Wanjohi  5 , Victor Mbewa  1   3 , Florentius Ndinya  6 , Sheila Eshiwani  7 , Simon Wahome  7 , Sanjay Bhagani  8 , Anton Pozniak  9 , Celia L Gregson  10   11
Affiliations
Randomized Controlled Trial

High prevalence of osteoporosis among virally suppressed older people (≥60 years) living with HIV

Jeremy Penner et al. HIV Med. 2025 Mar.

Abstract

Objectives: Our objective was to evaluate bone mineral density (BMD) among older people living with HIV at the time of enrolment into a clinical trial in Kenya.

Methods: The bictegravir/emtricitabine/tenofovir alafenamide (BFTAF) Elderly Study is a clinical trial among virally suppressed people living with HIV aged ≥60 years randomized to switch to BFTAF or continue their pre-enrolment regimen. At enrolment, dual-energy x-ray absorptiometry (DXA) of the lumbar spine, total hip, and femoral neck was performed and T-scores calculated for BMD. Osteoporosis was defined as T-score -2.5 or lower and osteopenia as T-score between -1 and -2.5. Fracture risk was calculated based on clinical risk factors (not including BMD), considering HIV as a secondary cause of osteoporosis, and the correlation between FRAX®-HIV and BMD assessed.

Results: Between February and May 2022, a total of 296 participants were enrolled. All were Black African, 147 (49.7%) were female, the median age was 64 years (range 60-77), and 280 (94.6%) were on tenofovir disoproxil fumarate. The median BMD of lumbar spine, total hip, and femoral neck was 0.87 g/cm2 (interquartile range [IQR] 0.78-0.99), 0.89 g/cm2 (IQR 0.79-1.01), and 0.75 g/cm2 (IQR 0.67-0.84), respectively, with median T-scores of -1.9 (IQR -2.8 to -0.7), -1.0 (IQR -1.9 to -0.3), and -1.5 (IQR -2.2 to -0.9), respectively. Osteoporosis and osteopenia were found in 37.5% and 47.3% of participants, respectively. Major osteoporotic fracture and hip fracture 10-year median probabilities using FRAX®-HIV were 3.4% (IQR 2.8-4.6) and 1.0% (IQR 0.7-1.3). Correlation coefficients between these FRAX®-HIV probabilities and femoral neck BMD were -0.204 for major osteoporotic fracture and -0.338 for hip fracture.

Conclusions: The prevalence of osteoporosis is high among older people living with HIV in Kenya, where DXA is not readily available and risk calculation without BMD had low correlation with measured BMD values. Additional data are required on the impact of investment in fracture risk assessment and treatment, including population-specific risk calculators.

Keywords: aging; bone mineral density; osteopenia; osteoporosis; sub‐Saharan Africa.

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References

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