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. 2024 Dec 1;46(6):cjae064.
doi: 10.1093/ejo/cjae064.

Indicators of transparency and data sharing in scientific writing in published randomized controlled trials in orthodontic journals between 2019 and 2023: an empirical study

Sophie Schueller  1 , Filippos Mikelis  2 , Theodore Eliades  1 , Despina Koletsi  1   3
Affiliations

Indicators of transparency and data sharing in scientific writing in published randomized controlled trials in orthodontic journals between 2019 and 2023: an empirical study

Sophie Schueller et al. Eur J Orthod. .

Abstract

Aim: To identify data sharing practices of authors of randomized-controlled trials (RCTs) in indexed orthodontic journals and explore associations between published reports and several publication characteristics.

Materials and methods: RCTs from indexed orthodontic journals in major databases, namely PubMed® (Medline), Scopus®, EMBASE®, and Web of Science™, were included from January 2019 to December 2023. Data extraction was conducted for outcome and predictor variables such as data and statistical code sharing practices reported, protocol registration, funding sources, and other publication characteristics, including the year of publication, journal ranking, the origin of authorship, number of authors, design of the RCT, and outcome-related variables (e.g. efficacy/safety). Statistical analyses included descriptive statistics, cross-tabulations, and univariable and multivariable logistic regression.

Results: A total of 318 RCTs were included. Statement for intention of the authors to provide their data upon request was recorded in 51 of 318 RCTs (16.0%), while 6 of 318 (1.9%) openly provided their data in repositories. No RCT provided any code or script for statistical analysis. A significant association was found between data sharing practices and the year of publication, with increasing odds for data sharing by 1.56 times across the years (odds ratio [OR]: 1.56; 95% confidence interval [CI]: 1.22, 2.01; P < .001). RCTs reporting on safety outcomes presented 62% lower odds for including positive data sharing statements compared to efficacy outcomes (OR: 0.38; 95% CI: 0.17, 0.88). There was evidence that funded RCTs were more likely to report on data sharing compared to non-funded (P = .02).

Conclusions: Albeit progress has been made towards credibility and transparency in the presentation of findings from RCTs in orthodontics, less than 20% of published orthodontic trials include a positive data sharing statement while less than 2% openly provide their data with publication.

Keywords: data sharing; individual participant data; orthodontic RCTs; registration; transparency.

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Conflict of interest statement

None declared.

Figures

Figure 1.
Figure 1.
Bar graph of data sharing practices of RCTs across all indexed orthodontic journals.
See this image and copyright information in PMC

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References

    1. Goodman SN, Fanelli D, Ioannidis JPA.. What does research reproducibility mean? Science Translational Medicine 2016;96:102. - PubMed
    1. Wallach JD, Boyack KW, Ioannidis JPA.. Reproducible research practices, transparency, and open access data in the biomedical literature, 2015–2017. PLoS Biology 2018;16:e2006930. https://doi.org/10.1371/journal.pbio.2006930 - DOI - PMC - PubMed
    1. McKiernan EC, Bourne PE, Brown CT, et al.How open science helps researchers succeed. Elife 2016;5:1–19. - PMC - PubMed
    1. Shahin MH, Bhattacharya S, Silva D, et al.Open data revolution in clinical research: opportunities and challenges. Clinical and Translational Science 2020;13:665–74. https://doi.org/10.1111/cts.12756 - DOI - PMC - PubMed
    1. Ioannidis JPA. Why most published research findings are false. PLoS Medicine 2005;2:e124. https://doi.org/10.1371/journal.pmed.0020124 - DOI - PMC - PubMed