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. 1986;3(1):39-52.
doi: 10.1002/gepi.1370030105.

Construction of human linkage maps: likelihood calculations for multilocus linkage analysis

G M Lathrop, J M Lalouel, R L White

Construction of human linkage maps: likelihood calculations for multilocus linkage analysis

G M Lathrop et al. Genet Epidemiol. 1986.

Abstract

Methods are given for efficient calculation of the likelihood for multilocus linkage in families comprised of grandparents, parents, and children. Such families are being used in large-scale cooperative efforts to build a detailed linkage map of the human genome. The methods are illustrated by an application to loci on chromosome 13.

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