Inflammatory Waldenström macroglobulinemia is associated with clonal hematopoiesis: a multicentric cohort

Pierre-Edouard Debureaux^{1

2

3}, Stéphanie Poulain⁴, Stéphanie Harel³, Marie Passet^{5

6}, Marie Templé⁷, Chloé Friedrich⁷, Nathalie Forgeard³, Dikelele Elessa³, William Plas⁶, Laureen Chat⁶, Grégory Lazarian⁸, Lise Willems⁹, Bruno Royer³, Alexis Talbot³, Tristan Vaugeois³, Floriane Theves³, Alexandre Terré¹⁰, Anne Brignier¹¹, Marion Malphettes¹², Daphné Krzisch^{13

14}, Laurent Frenzel¹⁵, Frédéric Davi^{16

17}, Clotilde Bravetti¹⁶, Florence Nguyen-Khac^{18

19}, Jehan Dupuis²⁰, Wendy Cuccuini⁶, Didier Bouscary⁹, Olivier Hermine¹⁵, Damien Roos-Weil^{16

19}, Olivier Kosmider⁷, Emmanuelle Clappier^{5

6}, Marion Espéli^{1

2}, Karl Balabanian^{1

2}, Bertrand Arnulf³

Affiliations

¹ Institut de Recherche Saint-Louis, University Paris Cité, INSERM U1160, Paris, France.
² OPALE Carnot Institute, Saint-Louis Hospital, Paris, France.
³ Department of Immuno-Hematology, Saint-Louis Hospital, Paris, France.
⁴ Hematology Laboratory, Lille Unité Mixte de Recherche en Santé Hospital, Lille, France.
⁵ Institut de Recherche Saint-Louis, University Paris Cité, INSERM U944/Unité Mixte de Recherche 7212, Paris, France.
⁶ Hematology Laboratory, Saint-Louis Hospital, Paris, France.
⁷ Hematobiology Unit, Cochin Hospital, Paris, France.
⁸ Hematobiology Unit, Avicenne Hospital, Paris, France.
⁹ Hematology Unit, Cochin Hospital, Paris, France.
¹⁰ Internal Medicine Unit, Tenon Hospital, Paris, France.
¹¹ Apheresis Unit, Saint-Louis Hospital, Paris, France.
¹² Immunopathology Unit, Saint-Louis Hospital, Paris, France.
¹³ Immuno-Oncology Unit, Saint-Louis Hospital, Paris, France.
¹⁴ Université Paris Cité, INSERM U1153, Paris, France.
¹⁵ Hematology Unit, Necker Hospital, Paris, France.
¹⁶ Department of Hematology, Pitié-Salpêtrière Hospital, Paris, France.
¹⁷ Sorbonne University, Paris, France.
¹⁸ Laboratory of Cytogenetic, Pitié-Salpêtrière Hospital, Paris, France.
¹⁹ Sorbonne Université, INSERM Unité Mixte de Recherche en Santé 1138, Drug Resistance in Hematological Malignancies Team, Centre de Recherche des Cordeliers, Paris, France.
²⁰ Department of Lymphoid Malignancies, Henri Mondor Hospital, Paris, France.

PMID: 39571148
DOI: 10.1182/blood.2024025738

Multicenter Study

Inflammatory Waldenström macroglobulinemia is associated with clonal hematopoiesis: a multicentric cohort

Pierre-Edouard Debureaux et al. Blood. 2025.

. 2025 Jan 23;145(4):450-454.

doi: 10.1182/blood.2024025738.

Authors

Affiliations

¹ Institut de Recherche Saint-Louis, University Paris Cité, INSERM U1160, Paris, France.
² OPALE Carnot Institute, Saint-Louis Hospital, Paris, France.
³ Department of Immuno-Hematology, Saint-Louis Hospital, Paris, France.
⁴ Hematology Laboratory, Lille Unité Mixte de Recherche en Santé Hospital, Lille, France.
⁵ Institut de Recherche Saint-Louis, University Paris Cité, INSERM U944/Unité Mixte de Recherche 7212, Paris, France.
⁶ Hematology Laboratory, Saint-Louis Hospital, Paris, France.
⁷ Hematobiology Unit, Cochin Hospital, Paris, France.
⁸ Hematobiology Unit, Avicenne Hospital, Paris, France.
⁹ Hematology Unit, Cochin Hospital, Paris, France.
¹⁰ Internal Medicine Unit, Tenon Hospital, Paris, France.
¹¹ Apheresis Unit, Saint-Louis Hospital, Paris, France.
¹² Immunopathology Unit, Saint-Louis Hospital, Paris, France.
¹³ Immuno-Oncology Unit, Saint-Louis Hospital, Paris, France.
¹⁴ Université Paris Cité, INSERM U1153, Paris, France.
¹⁵ Hematology Unit, Necker Hospital, Paris, France.
¹⁶ Department of Hematology, Pitié-Salpêtrière Hospital, Paris, France.
¹⁷ Sorbonne University, Paris, France.
¹⁸ Laboratory of Cytogenetic, Pitié-Salpêtrière Hospital, Paris, France.
¹⁹ Sorbonne Université, INSERM Unité Mixte de Recherche en Santé 1138, Drug Resistance in Hematological Malignancies Team, Centre de Recherche des Cordeliers, Paris, France.
²⁰ Department of Lymphoid Malignancies, Henri Mondor Hospital, Paris, France.

PMID: 39571148
DOI: 10.1182/blood.2024025738

Abstract

Inflammatory form of Waldenström macroglobulinemia (iWM) predicts outcomes after immuno-chemotherapy and Bruton tyrosine kinase inhibitors, but its origin is unknown. Here, we unravel increased clonal hematopoiesis in patients with iWM (61% vs 23% in noninflammatory WM), suggesting a contribution of environmental cells to iWM.

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Conflict of interest statement

Conflict-of-interest disclosure: The authors declare no competing financial interests.

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Inflammatory Waldenström macroglobulinemia is associated with clonal hematopoiesis: a multicentric cohort

Affiliations

Inflammatory Waldenström macroglobulinemia is associated with clonal hematopoiesis: a multicentric cohort

Authors

Affiliations

Abstract

Conflict of interest statement

References

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources