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. 2024 Dec;40(12):1069-1071.
doi: 10.1016/j.pt.2024.11.002. Epub 2024 Nov 20.

Multiomic interrogation of an endomembrane disrupting antimalarial

Sophie L Collier  1 , Stuart A Ralph  2
Affiliations

Multiomic interrogation of an endomembrane disrupting antimalarial

Sophie L Collier et al. Trends Parasitol. 2024 Dec.

Abstract

Challenges in adapting natural products as antimalarials include their cryptic mechanism of action (and by extension resistance), as well as their complex and expensive synthesis without an abundant natural source. Recently, Chahine et al. presented plausible means to address these challenges in the case of the kalihinol family of isocyanoterpenes.

Keywords: Plasmodium; apicoplast; endoplasmic reticulum; kalihinol; malaria.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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