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. 2025 Jan;41(1):4-5.
doi: 10.1016/j.tig.2024.10.013. Epub 2024 Nov 20.

PIC-king apart PRC1-mediated repression

Evan Healy  1 , Adrian P Bracken  2
Affiliations
Free article

PIC-king apart PRC1-mediated repression

Evan Healy et al. Trends Genet. 2025 Jan.
Free article

Abstract

Polycomb repressive complex 1 (PRC1) is an essential repressor of lineage-specific genes central to the establishment and preservation of cellular identity. Recent findings by Szczurek et al. show that the noncanonical form of PRC1 (ncPRC1), which mediates H2AK119ub1, promotes a deep OFF state at promoters by blocking transcription initiation.

Keywords: Polycomb; gene repression; live-cell imaging; ncPRC1; transcription.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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