Comparative Study
Study on the absorption of ketoprofen topically administered in man: comparison between tissue and plasma levels
- PMID: 3957503
Item in Clipboard
Comparative Study
Study on the absorption of ketoprofen topically administered in man: comparison between tissue and plasma levels
Int J Clin Pharmacol Res.
1986.
Abstract
In this study the transcutaneous passage of ketoprofen (gel) topically administered and its distribution in the inner part of the knee-joint were evaluated in six patients. The ketoprofen concentrations detected were: 4.70 mcg/g +/- 3.87 in the intra-articular adipose tissue; 2.35 mcg/g +/- 2.41 in the capsular sample and 1.31 mcg/g +/- 0.89 in the synovial fluid. Plasma concentrations of the drug were also examined. In the samples studied, the ketoprofen levels amounted to about one hundred times higher than the plasma concentrations.
Similar articles
-
[Pharmacokinetics of ketoprofen in the synovial fluid].Sem Hop. 1983 Dec 12;59(46):3208-9. Sem Hop. 1983. PMID: 6318342 French.
-
[Drug concentrations in blood, synovial fluid, synovial membrane, periarticular bone, muscle and adipose tissue in patients with rheumatoid polyarthritis receiving a single intramuscular injection of ketoprofen or acetylsalicylic acid (3 hours after the injection)].Sem Hop. 1983 Dec 12;59(46):3210-3. Sem Hop. 1983. PMID: 6318343 French.
-
Tissue absorption and distribution of ketoprofen after patch application in subjects undergoing knee arthroscopy or endoscopic carpal ligament release.Arzneimittelforschung. 2002;52(11):822-7. doi: 10.1055/s-0031-1299974. Arzneimittelforschung. 2002. PMID: 12489253 Clinical Trial.
-
[Chronokinetics of ketoprofen administered orally and by continuous venous infusion].Rev Rhum Mal Osteoartic. 1985 Jun;52(6):403-8. Rev Rhum Mal Osteoartic. 1985. PMID: 4048810 French.
-
Blood level studies on ketoprofen.Rheumatol Rehabil. 1978;Suppl:64-70. doi: 10.1093/rheumatology/xvii.suppl.64. Rheumatol Rehabil. 1978. PMID: 364614 Review. No abstract available.
Cited by
-
The topical anti-inflammatory and analgesic properties of bromfenac in rodents.Agents Actions. 1988 Aug;25(1-2):77-85. doi: 10.1007/BF01969098. Agents Actions. 1988. PMID: 3189047
-
Clinical pharmacokinetics of ketoprofen and its enantiomers.Clin Pharmacokinet. 1990 Sep;19(3):197-217. doi: 10.2165/00003088-199019030-00004. Clin Pharmacokinet. 1990. PMID: 2203580 Review.
-
Topical nonsteroidal anti-inflammatory drugs for the treatment of pain due to soft tissue injury: diclofenac epolamine topical patch.J Pain Res. 2010 Nov 10;3:223-33. doi: 10.2147/JPR.S13238. J Pain Res. 2010. PMID: 21197326 Free PMC article.
-
Percutaneous absorption of ketoprofen from different anatomical sites in man.Pharm Res. 1996 Jan;13(1):168-72. doi: 10.1023/a:1016014308638. Pharm Res. 1996. PMID: 8668669 Clinical Trial.
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources