Role of natural killer cells in intraocular melanoma metastasis
- PMID: 3957568
Item in Clipboard
Role of natural killer cells in intraocular melanoma metastasis
Invest Ophthalmol Vis Sci.
1986 Apr.
Abstract
The authors studied the role of natural killer (NK) cells in spontaneous metastasis of murine intraocular melanoma by transplanting murine B16 melanoma cells into the anterior chamber of the eye in syngeneic C57BL/6 mice and determining the number of metastatic lung tumor colonies after 40 days. Depletion of NK activity by anti-asialo GM1 serum dramatically enhanced metastasis and augmentation of NK activity by interferon inhibited it. The strong correlation between host NK activity and intraocular melanoma metastasis indicated that NK cells have an important role in spontaneous metastasis of intraocular melanoma.
Similar articles
-
Experimental model for metastasis of intraocular melanoma: preventive role of natural killer cells.Jpn J Ophthalmol. 1989;33(1):76-84. Jpn J Ophthalmol. 1989. PMID: 2733256
-
Synergistic defense system by cooperative natural effectors against metastasis of B16 melanoma cells in H-2-associated control: different behavior of H-2+ and H-2- cells in metastatic processes.J Immunol. 1986 Jun 15;136(12):4729-34. J Immunol. 1986. PMID: 3711664
-
Role of natural killer cells in tumor growth and metastasis: C57BL/6 normal and beige mice.J Natl Cancer Inst. 1980 Nov;65(5):929-35. J Natl Cancer Inst. 1980. PMID: 6933263
-
Recognition and destruction of tumor cells by natural killer cells.Ann Ist Super Sanita. 1988;24(1):83-8. Ann Ist Super Sanita. 1988. PMID: 3289446 Review. No abstract available.
-
Influence of immune surveillance and immune privilege on formation of intraocular tumors.Chem Immunol Allergy. 2007;92:276-289. doi: 10.1159/000099278. Chem Immunol Allergy. 2007. PMID: 17264503 Review.
MeSH terms
LinkOut - more resources
Full Text Sources
Medical
