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Review
. 2024 Nov 18;186(47):V06240429.
doi: 10.61409/V06240429.

Chimeric antigen receptor T-cell therapy for refractory systemic autoimmune rheumatological diseases

[Article in Danish]
Mads Lamm Larsen  1   2 , Anne Voss  3 , Christoffer Tandrup Holst Nielsen  4 , Ellen-Margrethe Hauge  1   5 , Mikkel Faurschou  4 , Anne Troldborg  1   2   5
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Free article
Review

Chimeric antigen receptor T-cell therapy for refractory systemic autoimmune rheumatological diseases

[Article in Danish]
Mads Lamm Larsen et al. Ugeskr Laeger. .
Free article

Abstract

Chimeric antigen receptor T-cell (CAR-T) therapy is emerging as a novel treatment for systemic autoimmune rheumatic diseases. To date, CAR-T therapy in rheumatology has been reported only in case studies and conference abstracts, but clinical trial results are forthcoming. Current evidence indicates a rapid and highly effective therapeutic response with a favourable side effect profile, suggesting that CD19 CAR-T therapy could be beneficially established for these conditions. Initially, CAR-T therapy appears relevant for a select group of severe, treatment-resistant rheumatic diseases.

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