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Review
. 2024 Nov 22;27(1):8.
doi: 10.1007/s11883-024-01250-2.

Role of RNA-binding Proteins in Regulating Cell Adhesion and Progression of the Atherosclerotic Plaque and Plaque Erosion

Ying Cao  1 , Yanyan Yang  2 , Chuan Guo  3 , Jinbao Zong  1 , Min Li  1 , Xiaolu Li  4 , Tao Yu  5   6   7
Affiliations
Review

Role of RNA-binding Proteins in Regulating Cell Adhesion and Progression of the Atherosclerotic Plaque and Plaque Erosion

Ying Cao et al. Curr Atheroscler Rep. .

Abstract

Purpose of review: RNA-binding proteins (RBPs) have emerged as crucial regulators of post-transcriptional processes, influencing the fate of RNA. This review delves into the biological functions of RBPs and their role in alternative splicing concerning atherosclerosis (AS), highlighting their participation in essential cellular processes. Our goal is to offer new insights for cardiovascular disease research and treatment.

Recent finding: Dysregulation of RBPs is associated with various human diseases, including autoimmune and neurological disorders. The role of RBPs in the pathogenesis of AS is progressively being elucidated, as they influence plaque formation and disease progression by regulating cell function and gene expression. RBPs play intricate biological roles in regulating pre-mRNA, including editing, splicing, stability and translation. Alternative splicing has been demonstrated to enhance biological complexity and diversity. Our findings indicate that alternative splicing is extensively involved in the pathogenesis of AS. The dysregulated expression of specific RBPs in AS is linked to the production of adhesion molecules and vascular endothelium damage. Further research on RBPs could pave the way for the development of novel therapeutic targets.

Keywords: Adhesion; Alternative splicing; Atherosclerosis; Inflammation; RNA-binding proteins.

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Conflict of interest statement

Declarations. Competing Interests: The authors declare no competing interests. Human and Animal Rights: This article does not contain any studies with human or animal subjects performed by any of the authors.

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