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Case Reports
. 2025 Feb;18(1):62-66.
doi: 10.1007/s12328-024-02065-z. Epub 2024 Nov 22.

A case of gastric granular cell tumor successfully treated by laparoscopic and endoscopic cooperative surgery

Kyoko Arahata  1 , Sakiko Takarabe  1 , Kenji Nakamura  2 , Yasue Fujikawa  1   3 , Tadashi Katayama  1 , Keisuke Ojiro  1 , Hiroshi Kishikawa  1 , Aya Sasaki  4 , Hirotoshi Hasegawa  5 , Jiro Nishida  1
Affiliations
Case Reports

A case of gastric granular cell tumor successfully treated by laparoscopic and endoscopic cooperative surgery

Kyoko Arahata et al. Clin J Gastroenterol. 2025 Feb.

Abstract

We describe a case of gastric granular cell tumor (GCT) treated with laparoscopic and endoscopic cooperative surgery (LECS). A 30-year-old male was referred to our hospital for the investigation of a subepithelial lesion (SEL). Contrast-enhanced computed tomography and esophagogastroduodenoscopy revealed a 15 mm SEL within the posterior wall of the gastric body. Endoscopic ultrasound revealed a well-demarcated, homogenous, hypoechoic lesion in the submucosa, suggesting partial invasion into the muscularis propria. Biopsy using the bite-on-bite technique showed a gastric GCT diagnosis. The patient underwent LECS, and pathological findings confirmed a benign gastric GCT without muscularis propria invasion, lymphovascular invasion, or lymph node metastasis. The patient remained recurrence-free after 24 months.Despite unresolved issues such as setting the resection margins; indications for resection, and accurate preoperative diagnosis of the invasion depth, including muscularis propria invasion, LECS may be useful for gastric GCT in the form of SEL, especially for lesions that cannot be ruled out to invade the muscularis propria invasion.

Keywords: Granular cell tumor; Laparoscopic and endoscopic cooperative surgery; Stomach; Subepithelial lesion.

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Conflict of interest statement

Declarations. Conflict of interest: The authors declare that they have no conflict of interest. Human/animal rights: All procedures followed were in accordance with the ethical standard of the responsible committee on human experimentation (institutional and national) and with Helsinki Declaration of 1975, as revised in 2008(5). Informed consent: Informed consent was obtained from the patient included in the study.

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