Beyond static measurements: dynamic frailty improves survival prediction in multiple myeloma

doi:10.1182/blood.2024025868

. 2025 Jan 30;145(5):543-546.

doi: 10.1182/blood.2024025868.

Beyond static measurements: dynamic frailty improves survival prediction in multiple myeloma

Febe Smits^{1

2

3}, Kaz Groen^{1

2}, Mark-David Levin⁴, Claudia A M Stege⁵, Roel van Kampen⁶, Ellen van der Spek⁷, Yavuz M Bilgin⁸, Noortje Thielen⁹, Inger Nijhof¹⁰, Inge Ludwig¹¹, Esther G M de Waal¹², Yorick Sandberg¹³, Alain Kentos¹⁴, Gert-Jan Timmers¹⁵, Josien C Regelink¹⁶, Matthijs Westerman¹⁷, Koen de Heer¹⁸, Marie-Christiane Vekemans¹⁹, Nazik Durdu-Rayman²⁰, Nicole C H P de Graauw²¹, Maarten R Seefat^{1

2}, Niels W C J van de Donk^{1

2}, Paula F Ypma³, Kazem Nasserinejad⁵, Sonja Zweegman^{1

2}

Affiliations

¹ Department of Hematology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
² Treatment and Quality of Life, Cancer Center Amsterdam, Amsterdam, The Netherlands.
³ Department of Hematology, Haga Hospital, The Hague, The Netherlands.
⁴ Department of Internal Medicine, Albert Schweitzer Hospital, Dordrecht, The Netherlands.
⁵ Department of Hematology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
⁶ Department of Internal Medicine, Zuyderland Hospital, Sittard, The Netherlands.
⁷ Department of Internal Medicine, Rijnstate Hospital, Arnhem, The Netherlands.
⁸ Department of Internal Medicine, Ardz Hospital, Goes, The Netherlands.
⁹ Department of Internal Medicine, Diakonessenhuis, Utrecht, The Netherlands.
¹⁰ Department of Internal Medicine, Antonius Hospital, Nieuwegein, The Netherlands.
¹¹ Department of Hematology, Bernhoven Hospital, Uden, The Netherlands.
¹² Department of Internal Medicine, Medical Center Leeuwarden, Leeuwarden, The Netherlands.
¹³ Department of Internal Medicine, Maasstad Hospital, Rotterdam, The Netherlands.
¹⁴ Department of Hematology, Centre Hospitalier Jolimont, Haine-Saint-Paul, Belgium.
¹⁵ Department of Internal Medicine, Amstelland Hospital, Amstelveen, The Netherlands.
¹⁶ Department of Internal Medicine, Meander Medical Center, Amersfoort, The Netherlands.
¹⁷ Department of Internal Medicine, Northwest Clinics, Alkmaar, The Netherlands.
¹⁸ Department of Internal Medicine, Flevoziekenhuis, Almere, The Netherlands.
¹⁹ Department of Hematology, Cliniques universitaires Saint-Luc, Brussels, Belgium.
²⁰ Department of Internal Medicine, Franciscus Hospital, Schiedam, The Netherlands.
²¹ Department of Internal Medicine, Bravis Hospital, Roosendaal, The Netherlands.

PMID: 39576961
DOI: 10.1182/blood.2024025868

Beyond static measurements: dynamic frailty improves survival prediction in multiple myeloma

Febe Smits et al. Blood. 2025.

. 2025 Jan 30;145(5):543-546.

doi: 10.1182/blood.2024025868.

Authors

Affiliations

¹ Department of Hematology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
² Treatment and Quality of Life, Cancer Center Amsterdam, Amsterdam, The Netherlands.
³ Department of Hematology, Haga Hospital, The Hague, The Netherlands.
⁴ Department of Internal Medicine, Albert Schweitzer Hospital, Dordrecht, The Netherlands.
⁵ Department of Hematology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
⁶ Department of Internal Medicine, Zuyderland Hospital, Sittard, The Netherlands.
⁷ Department of Internal Medicine, Rijnstate Hospital, Arnhem, The Netherlands.
⁸ Department of Internal Medicine, Ardz Hospital, Goes, The Netherlands.
⁹ Department of Internal Medicine, Diakonessenhuis, Utrecht, The Netherlands.
¹⁰ Department of Internal Medicine, Antonius Hospital, Nieuwegein, The Netherlands.
¹¹ Department of Hematology, Bernhoven Hospital, Uden, The Netherlands.
¹² Department of Internal Medicine, Medical Center Leeuwarden, Leeuwarden, The Netherlands.
¹³ Department of Internal Medicine, Maasstad Hospital, Rotterdam, The Netherlands.
¹⁴ Department of Hematology, Centre Hospitalier Jolimont, Haine-Saint-Paul, Belgium.
¹⁵ Department of Internal Medicine, Amstelland Hospital, Amstelveen, The Netherlands.
¹⁶ Department of Internal Medicine, Meander Medical Center, Amersfoort, The Netherlands.
¹⁷ Department of Internal Medicine, Northwest Clinics, Alkmaar, The Netherlands.
¹⁸ Department of Internal Medicine, Flevoziekenhuis, Almere, The Netherlands.
¹⁹ Department of Hematology, Cliniques universitaires Saint-Luc, Brussels, Belgium.
²⁰ Department of Internal Medicine, Franciscus Hospital, Schiedam, The Netherlands.
²¹ Department of Internal Medicine, Bravis Hospital, Roosendaal, The Netherlands.

PMID: 39576961
DOI: 10.1182/blood.2024025868

Abstract

The level of frailty, according to the International Myeloma Working Group frailty index, is highly dynamic during antimyeloma treatment. Dynamic frailty assessment improved the prediction of survival and early mortality compared with the prognostic value of static frailty level at baseline.

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Beyond static measurements: dynamic frailty improves survival prediction in multiple myeloma

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Beyond static measurements: dynamic frailty improves survival prediction in multiple myeloma

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