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. 2024 Dec;34(4):101520.
doi: 10.1016/j.mycmed.2024.101520. Epub 2024 Nov 14.

Laboratory practices for the diagnosis and management of mucormycosis in France, 2024

Laurence Millon  1 , Françoise Botterel  2 , Julie Bonhomme  3 , Stéphane Valot  4 , Philippe Poirier  5 , Marie-Fleur Durieux  6 , Jeanne Bigot  7 , Guillaume Desoubeaux  8 , Adélaïde Chesnais  8 , Florent Morio  9 , Marc Pihet  10 , Kévin Brunet  11 , Anne-Pauline Bellanger  12 , Sébastien Imbert  13 , Gilles Nevez  14 , Solène Le Gal  14 , Nathalie Bourgeois  15 , Anne Debourgogne  16 , Marjorie Cornu  17 , Florence Persat  18 , Lilia Hasseine  19 , Marie-Elisabeth Bougnoux  20 , Sophie Brun  21 , Muriel Cornet  22 , Loïc Favennec  23 , Gilles Gargala  23 , Christine Bonnal  24 , Jean-Pierre Gangneux  25 , Alexandre Alanio  26 , Xavier Iriart  27 , Caroline Mahinc  28 , Taieb Chouaki  29 , André Paugam  30 , Valérie Letscher-Bru  31 , Eric Dannaoui  32
Affiliations
Free article

Laboratory practices for the diagnosis and management of mucormycosis in France, 2024

Laurence Millon et al. J Mycol Med. 2024 Dec.
Free article

Abstract

This study investigates the diagnostic practices for mucormycosis among 30 French University Hospital mycology laboratories, in 2024. All laboratories perform both direct examination and culture, with fluorescent brighteners being the most commonly used method for direct examination. While 77 % of the participating laboratories routinely identify Mucorales to the species level, with 70 % having adopted Mucorales-specific quantitative PCR, primarily for the diagnosis of invasive fungal infections. Antifungal susceptibility testing practices varied between centers, with 36.7 % of laboratories consistently performing these tests, primarily using gradient concentration strips. Amphotericin B, posaconazole, and isavuconazole were the most frequently tested antifungals. These findings highlight variations in laboratory practices and emphasize the importance of establishing uniform diagnostic and susceptibility testing methods to optimize mucormycosis management.

Keywords: Laboratory practice; Mucorales; Mucormycosis.

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Conflict of interest statement

Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Eric Dannaoui has received research grants from Biomérieux: travel grants from Gilead, Mundipharma, and Pfizer; speaker's fee from Mundipharma, Pfizer, and Gilead. Kévin Brunet has received travel grants from Pfizer and Gilead and speaker's fee from Gilead. Laurence Millon has received travel grants from Gilead and Pfizer; speaker's fee from Gilead and Pfizer. Marjorie Cornu received travel grants and speaker's fee from Gilead and Pfizer. The other authors have no conflicts of interest to disclose.

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