Signaling pathways in skin cancers and the protective functions of melatonin

Abstract

Melatonin, a hormone primarily synthesized in the pineal gland, has an essential role in the regulation of various physiological processes, such as the sleep-wake cycle, immune function, and antioxidative responses. Emerging evidence suggests that melatonin also exerts significant protective effects against skin cancers, particularly melanoma and non-melanoma skin cancers. This review aims to provide a comprehensive overview of melatonin's multifaceted mechanisms of action in preventing and treating skin cancers, focusing on its antioxidant, photoprotective, and radioprotective properties. Melatonin's capability to modulate skin cancer's related key signaling pathways underscores its complex yet potent anticancer mechanisms. Furthermore, synergistic effects between melatonin and conventional oncology treatments, such as radiotherapy, chemotherapy, and targeted therapies, hold promise for improving treatment outcomes while mitigating adverse effects. However, while melatonin shows great potential as an adjunct in oncology treatment regimens, further research is needed to optimize its clinical applications and fully understand its safety profile and potential side effects. Overall, elucidating melatonin's role in skin cancer prevention and treatment represents a promising avenue for advancing cancer therapeutics and improving patient outcomes.

Keywords: Cancer; Chemotherapy; Melatonin; Pharmacology; Radiotherapy; Skin.