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Editorial
. 2025 Feb;21(2):257-259.
doi: 10.1080/15548627.2024.2419112. Epub 2024 Nov 22.

Autophagy-dependent ferroptosis mediates multiple sclerosis

Daolin Tang  1 , Rui Kang  1 , Daniel J Klionsky  2
Affiliations
Editorial

Autophagy-dependent ferroptosis mediates multiple sclerosis

Daolin Tang et al. Autophagy. 2025 Feb.

Abstract

A recent paper published in Cell by Woo et al. reported that autophagy-dependent ferroptosis mediated by STING1 is involved in neuronal death associated with multiple sclerosis (MS). This research broadens our understanding of the pathogenesis of MS and opens new avenues for therapeutic interventions.

Keywords: Cell death; GPX4; STING1; macroautophagy; neurons.

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Conflict of interest statement

No potential conflict of interest was reported by the author(s).

Comment on

  • STING orchestrates the neuronal inflammatory stress response in multiple sclerosis.
    Woo MS, Mayer C, Binkle-Ladisch L, Sonner JK, Rosenkranz SC, Shaposhnykov A, Rothammer N, Tsvilovskyy V, Lorenz SM, Raich L, Bal LC, Vieira V, Wagner I, Bauer S, Glatzel M, Conrad M, Merkler D, Freichel M, Friese MA. Woo MS, et al. Cell. 2024 Jul 25;187(15):4043-4060.e30. doi: 10.1016/j.cell.2024.05.031. Epub 2024 Jun 14. Cell. 2024. PMID: 38878778

References

    1. Comi G, Dalla Costa G, Stankoff B, et al. Assessing disease progression and treatment response in progressive multiple sclerosis. Nat Rev Neurol. 2024;20(10):573–586. doi: 10.1038/s41582-024-01006-1 - DOI - PubMed
    1. Woo MS, Mayer C, Binkle-Ladisch L, et al. STING orchestrates the neuronal inflammatory stress response in multiple sclerosis. Cell. 2024;187(15):4043–60 e30. doi: 10.1016/j.cell.2024.05.031 - DOI - PubMed
    1. Srikanth S, Woo JS, Wu B, et al. The Ca(2+) sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum. Nat Immunol. 2019;20(2):152–162. doi: 10.1038/s41590-018-0287-8 - DOI - PMC - PubMed
    1. Gui X, Yang H, Li T, et al. Autophagy induction via STING trafficking is a primordial function of the cGAS pathway. Nature. 2019;567(7747):262–266. doi: 10.1038/s41586-019-1006-9 - DOI - PMC - PubMed
    1. Yang Z, Klionsky DJ.. Eaten alive: a history of macroautophagy. Nat Cell Biol. 2010;12(9):814–822. doi: 10.1038/ncb0910-814 - DOI - PMC - PubMed

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