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. 2024 Dec;45(12):925-927.
doi: 10.1016/j.it.2024.11.002. Epub 2024 Nov 22.

SARS-CoV-2 reprograms murine alveolar macrophages to dampen flu

Alexandra Tabachnikova  1 , Akiko Iwasaki  2
Affiliations

SARS-CoV-2 reprograms murine alveolar macrophages to dampen flu

Alexandra Tabachnikova et al. Trends Immunol. 2024 Dec.

Abstract

Innate immune cells that are epigenetically reprogrammed by infection can modify host responses to subsequent infections. Lercher et al. have identified epigenetic reprogramming of murine airway-resident macrophages following recovery from SARS-CoV-2 infection, conferring protection from pathology and lethality following secondary influenza A virus (IAV) challenge without reducing viral titers.

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Declaration of interests No interests are declared.

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